Document Detail

Perinatal asphyxia: a clinical review, including research with brain hypothermia.
MedLine Citation:
PMID:  12144213     Owner:  NLM     Status:  MEDLINE    
Perinatal asphyxia may occur in utero, during labor and delivery, or in the postnatal period. There are numerous causes, and the clinical manifestations vary. Infants who experience mild asphyxia may show no neurologic injury. Severe asphyxia may be fatal in utero, or immediately after birth, with survivors showing extensive neurologic sequelae, with or without cognitive deficits. Mild brain hypothermia appears promising in the prevention of further neurologic damage in encephalopathic infants following asphyxia. Recent research on newborn animal models has focused on the timing, duration, and depth of hypothermia. Promising new research is now under way in nurseries in the U.S. in an attempt to establish clinical protocols for use of hypothermia in human neonates.
N E Flavin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  20     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-08-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  N    
Magella Medical Associates, Dallas, TX 75243, USA.
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MeSH Terms
Asphyxia Neonatorum / complications,  diagnosis,  metabolism,  therapy*
Brain Chemistry
Clinical Protocols
Disease Models, Animal
Hypothermia, Induced / adverse effects,  methods*,  standards
Hypoxia, Brain / etiology,  prevention & control
Infant, Newborn
Intensive Care, Neonatal / methods,  standards
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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