| Perinatal aspects of iron metabolism. | |
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MedLine Citation:
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PMID: 12477276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron sufficiency is critical for rapidly developing fetal and neonatal organ systems. The majority of iron in the third trimester fetus and the neonate is found in the red cell mass (as hemoglobin), with lesser amounts in the tissues as storage iron (e.g. ferritin) or functional iron (e.g. myoglobin, cytochromes). Iron is prioritized to hemoglobin synthesis in red cells when iron supply does not meet iron demand. Thus, non-heme tissues such as the skeletal muscle, heart and brain will become iron deficient before signs of iron-deficiency anemia. Gestational conditions that result in lower newborn iron stores include severe maternal iron deficiency, maternal hypertension with intrauterine growth retardation and maternal diabetes mellitus. Stable, very low birthweight premature infants are also at risk for early postnatal iron deficiency because they accrete less iron during gestation, grow more rapidly postnatally, are typically undertreated with enteral iron and receive fewer red cell transfusions. Conversely, iron overload remains a significant concern in multiply transfused sick preterm infants because they have low levels of iron-binding proteins and immature antioxidant systems. CONCLUSION: The highly variable iron status of preterm infants combined with their risk for iron deficiency and toxicity warrants careful monitoring and support in the newborn and postdischarge periods. |
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Authors:
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R Rao; M K Georgieff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992). Supplement Volume: 91 ISSN: 0803-5326 ISO Abbreviation: Acta Paediatr Suppl Publication Date: 2002 |
Date Detail:
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Created Date: 2002-12-12 Completed Date: 2003-03-18 Revised Date: 2008-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9315043 Medline TA: Acta Paediatr Suppl Country: Norway |
Other Details:
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Languages: eng Pagination: 124-9 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics and Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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diagnosis*,
etiology,
therapy* Combined Modality Therapy Erythrocyte Transfusion / methods Erythropoietin, Recombinant / therapeutic use Female Fetal Growth Retardation / complications, diagnosis Follow-Up Studies Gestational Age Humans Infant, Newborn Infant, Premature* Iron Compounds / adverse effects, therapeutic use Iron Metabolism Disorders / complications, diagnosis*, therapy* Iron Overload / prevention & control* Maternal-Fetal Exchange Perinatology Pregnancy Risk Assessment Risk Factors Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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HD-29421/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Iron Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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