Document Detail


Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants.
MedLine Citation:
PMID:  14502008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The perinatal prophylactic administration of zidovudine is associated with rapidly reversible macrocytic anemia in infants. However, a recent study suggests that there may be more persistent inhibition of hematopoïetic stem cells. OBJECTIVE: To study hematopoiesis in uninfected infants, born to HIV-1 seropositive mothers, including those exposed and those not exposed to perinatal zidovudine alone or in combination. METHODS: Longitudinal study, from 0 to 18 months, of hemoglobin, platelets, polynuclear neutrophils, total lymphocytes, and CD4+ and CD8+ lymphocytes in more than 4000 infants of the French Perinatal Study. Modeling of repeated measures and non-linear evolution with age, with models combining natural cubic B-splines and random effects. RESULTS: The hemoglobin level was transiently reduced in newborns exposed to zidovudine. Multivariate analysis taking into account age, prematurity, geographical origin, maternal drug use and maternal CD4 cell count, indicated that levels of the three other lineages were slightly lower until age 18 months in exposed than not exposed infants (P < 0.0001 for each lineage). There was a negative relationship between the duration of exposure and each hematological variable. Combinations of antiretroviral treatments were associated with larger decreases than monotherapy up to 15 months of age. Similar, but less pronounced, patterns were found for the CD4+ and CD8+ subpopulations of lymphocytes. CONCLUSIONS: Zidovudine administered during the perinatal period may result in a small but significant and durable effect on hematopoïesis up to the age of 18 months.
Authors:
Jérôme Le Chenadec; Marie-Jeanne Mayaux; Chantal Guihenneuc-Jouyaux; Stéphane Blanche;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  17     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-22     Completed Date:  2003-12-15     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  2053-61     Citation Subset:  IM; X    
Affiliation:
INSERM U569, Epidémiologie, Démographie et Sciences Sociales, Hôpital Bicêtre AP-HP, 82 rue du Général Leclerc 94276 Le Kremlin Bicêtre Cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / therapeutic use*
CD4 Lymphocyte Count / methods
Female
HIV Infections / immunology,  physiopathology,  prevention & control*
HIV Seropositivity / complications*
HIV-1 / immunology
Hematopoiesis / physiology*
Hemoglobins / analysis
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Lymphocyte Subsets / immunology
Maternal-Fetal Exchange / immunology
Neutrophils / immunology
Platelet Count / methods
Pregnancy
Pregnancy Complications, Infectious / immunology*
Time Factors
Zidovudine / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Hemoglobins; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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