Document Detail


Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats.
MedLine Citation:
PMID:  20864654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The long-chain polyunsaturated n-6 and n-3 fatty acids are essential nutrients in membrane biogenesis and regulate gene expression via their eicosanoid metabolites. We investigated whether the n-6 and n-3 fatty acid supply as determined by maternal diet alters colonic phospholipid fatty acids, intestinal morphology, and epithelial barrier permeability during milk feeding with lasting effect on mucosal responsiveness to dinitrobenzene sulfonic acid (DNBS)-induced colitis in young adulthood. Female rats were fed diets with 20% energy from safflower oil (SO) or canola oil (CO), or 8% fish oil (FO) plus 2% SO (10% FO) or 18% FO plus 2% SO (20% FO) throughout gestation and lactation and offspring weaned to a standard diet at 21 days of age. At 15 days of age, pups in the 20% and 10% FO groups had lower 20:4n-6 and higher 20:5n-3 and 22:6n-3 in colon phospholipids (P < 0.01), shorter crypts (P < 0.05), and higher paracellular permeability than SO or CO groups. At 3 mo of age, male offspring in the FO groups showed lasting reduction of crypt depth and a heightened inflammatory response to DNBS. We demonstrate that early decreased colon 20:4n-6 with increased n-3 fatty acids impairs intestinal barrier development and sensitizes the colon response to inflammatory insults later in life.
Authors:
Sheila M Innis; Chuanbin Dai; Xiujuan Wu; Alison M J Buchan; Kevan Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-23
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  299     ISSN:  1522-1547     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G1376-85     Citation Subset:  IM    
Affiliation:
Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena
Animals
Colitis / chemically induced*,  physiopathology
Colon / physiology
Dietary Fats / pharmacology*
Dinitrofluorobenzene / analogs & derivatives,  toxicity
Female
Intestines / drug effects*,  growth & development*
Male
Maternal Nutritional Physiological Phenomena
Permeability
Pregnancy
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Dietary Fats; 143134-35-4/2,4-dinitrofluorobenzene sulfonic acid; 70-34-8/Dinitrofluorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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