| Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats. | |
| | |
MedLine Citation:
|
PMID: 20864654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The long-chain polyunsaturated n-6 and n-3 fatty acids are essential nutrients in membrane biogenesis and regulate gene expression via their eicosanoid metabolites. We investigated whether the n-6 and n-3 fatty acid supply as determined by maternal diet alters colonic phospholipid fatty acids, intestinal morphology, and epithelial barrier permeability during milk feeding with lasting effect on mucosal responsiveness to dinitrobenzene sulfonic acid (DNBS)-induced colitis in young adulthood. Female rats were fed diets with 20% energy from safflower oil (SO) or canola oil (CO), or 8% fish oil (FO) plus 2% SO (10% FO) or 18% FO plus 2% SO (20% FO) throughout gestation and lactation and offspring weaned to a standard diet at 21 days of age. At 15 days of age, pups in the 20% and 10% FO groups had lower 20:4n-6 and higher 20:5n-3 and 22:6n-3 in colon phospholipids (P < 0.01), shorter crypts (P < 0.05), and higher paracellular permeability than SO or CO groups. At 3 mo of age, male offspring in the FO groups showed lasting reduction of crypt depth and a heightened inflammatory response to DNBS. We demonstrate that early decreased colon 20:4n-6 with increased n-3 fatty acids impairs intestinal barrier development and sensitizes the colon response to inflammatory insults later in life. |
| | |
Authors:
|
Sheila M Innis; Chuanbin Dai; Xiujuan Wu; Alison M J Buchan; Kevan Jacobson |
Related Documents
:
|
20153394 - N-3 long-chain fatty acids and regulation of glucose transport in two models of rat bra... 12355064 - Low docosahexaenoic acid levels in rod outer segments of rats with p23h and s334ter rho... 16426224 - Evaluation of the effects of dietary n-3 fatty acid supplementation on the pharmacokine... 19443194 - Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cho... 2422874 - The fate of homologous nasal septal cartilages in tympanoplasty. 897864 - Effect of vitamin or amino acid supplementation on plasma free amino acid levels in sou... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-23 |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 299 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-02 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: G1376-85 Citation Subset: IM |
Affiliation:
|
Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Nutritional Physiological Phenomena Animals Colitis / chemically induced*, physiopathology Colon / physiology Dietary Fats / pharmacology* Dinitrofluorobenzene / analogs & derivatives, toxicity Female Intestines / drug effects*, growth & development* Male Maternal Nutritional Physiological Phenomena Permeability Pregnancy Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 143134-35-4/2,4-dinitrofluorobenzene sulfonic acid; 70-34-8/Dinitrofluorobenzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regional differences in colonic mucosa-associated microbiota determine the physiological expression ...
Next Document: Lower esophageal sphincter relaxation reflex kinetics: effects of peristaltic reflexes and maturatio...