Document Detail


Perinatal lamb model of respiratory syncytial virus (RSV) infection.
MedLine Citation:
PMID:  23202468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. Many animal models are used to study RSV, but most studies investigate disease in adult animals which does not address the unique physiology and immunology that makes infants more susceptible. The perinatal (preterm and term) lamb is a useful model of infant RSV disease as lambs have similar pulmonary structure including airway branching, Clara and type II cells, submucosal glands and Duox/lactoperoxidase (LPO) oxidative system, and prenatal alveologenesis. Lambs can be born preterm (90% gestation) and survive for experimentation although both preterm and term lambs are susceptible to ovine, bovine and human strains of RSV and develop clinical symptoms including fever, tachypnea, and malaise as well as mild to moderate gross and histologic lesions including bronchiolitis with epithelial injury, neutrophil infiltration and syncytial cell formation. RSV disease in preterm lambs is more severe than in term lambs; disease is progressively less in adults and age-dependent susceptibility is a feature similar to humans. Innate and adaptive immune responses by perinatal lambs closely parallel those of infants. The model is used to test therapeutic regimens, risk factors such as maternal ethanol consumption, and formalin inactivated RSV vaccines.
Authors:
Rachel J Derscheid; Mark R Ackermann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-23
Journal Detail:
Title:  Viruses     Volume:  4     ISSN:  1999-4915     ISO Abbreviation:  Viruses     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-16     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101509722     Medline TA:  Viruses     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2359-78     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathology, 2738 College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA. rdersch@iastate.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Antibodies, Viral / immunology
Disease Models, Animal*
Disease Susceptibility / immunology,  virology
Epithelial Cells / immunology,  pathology,  virology
Immunity, Innate*
Lactoperoxidase / immunology
Lung / immunology,  pathology,  virology*
Respiratory Syncytial Virus Infections / immunology*,  prevention & control,  virology
Respiratory Syncytial Virus Vaccines / immunology
Respiratory Syncytial Viruses / immunology,  pathogenicity*
Sheep
Tumor Necrosis Factor-alpha / immunology
Vaccination
Grant Support
ID/Acronym/Agency:
1R56AI091000-01A1/AI/NIAID NIH HHS; R01AI062787/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Respiratory Syncytial Virus Vaccines; 0/Tumor Necrosis Factor-alpha; EC 1.11.1.-/Lactoperoxidase
Comments/Corrections

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