Document Detail

Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats.
MedLine Citation:
PMID:  15184350     Owner:  NLM     Status:  MEDLINE    
Embryo cross-transplantation and cross-fostering between spontaneously hypertensive rats (SHR) and normotensive rats (WKY) suggest that perinatal environment modulates the genetically determined phenotype. In SHR the balance between NO and reactive oxygen species (ROS) is disturbed. We hypothesized that increasing NO and diminishing ROS in perinatal life would ameliorate hypertension in adult SHR. Pregnant SHR and WKY and their offspring received l-arginine plus antioxidants (vitamin C, vitamin E, and taurine) during the last 2 weeks of pregnancy and then until either 4 or 8 weeks after birth. Systolic blood pressure (SBP) and urinary excretion of protein, nitrates (NO(x)), and thiobarbituric acid reactive substances (TBARS) were measured. At 48 weeks of age rats were euthanized for glomerular counts. Perinatal supplements reduced SBP persistently in SHR and prevented the SBP increase observed in aging WKY. Initially NO(x) excretion was lower and TBARS excretion higher in SHR than WKY. There was a direct effect on NO(x) excretion in supplemented pregnant SHR and their offspring, but no increase was observed after stopping the supplements. TBARS excretion was only depressed up to 14 weeks by the supplements despite persistent differences in SBP. Consistent effects on nephron number were absent. Mild proteinuria, present in control SHR at 48 weeks, was prevented in all supplemented rats. Perinatal supplementation of NO substrate and antioxidants results in persistent reduction of SBP and renal protection in SHR, although effects on NO(x) and TBARS were only transient. This suggests a critical role for perinatal pro- and antioxidant balance in programming BP later in life.
Simona Racasan; Branko Braam; Dionne M van der Giezen; Roel Goldschmeding; Peter Boer; Hein A Koomans; Jaap A Joles
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-06-07
Journal Detail:
Title:  Hypertension     Volume:  44     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-25     Completed Date:  2004-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands.
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MeSH Terms
Aging / physiology*
Animals, Newborn
Antioxidants / pharmacology*
Arginine / pharmacology*
Blood Pressure / drug effects*
Dietary Supplements
Hypertension / prevention & control*
Kidney / physiology
Nitric Oxide / physiology
Oxidative Stress*
Rats, Inbred SHR
Rats, Inbred WKY
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide; 74-79-3/Arginine

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