| Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet. | |
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MedLine Citation:
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PMID: 21586551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bisphenol A (BPA), a widely used environmental endocrine disruptor, has been reported to disrupt glucose homeostasis. BPA exposure may be a risk factor for type 2 diabetes. In this study, we investigated the effects of early-life BPA exposure on metabolic syndrome in rat offspring fed a normal diet and a high-fat diet. Pregnant Wistar rats were exposed to BPA (50, 250, or 1250 μg/kg · d) or corn oil throughout gestation and lactation by oral gavage. Offspring were fed a normal diet or a high-fat diet after weaning. Body weight, parameters of glucose and lipid metabolism, morphology, and function of β-cells were measured in offspring. On a normal diet, perinatal exposure to 50 μg/kg · d BPA resulted in increased body weight, elevated serum insulin, and impaired glucose tolerance in adult offspring. On a high-fat diet, such detrimental effects were accelerated and exacerbated. Furthermore, severe metabolic syndrome, including obesity, dyslipidemia, hyperleptindemia, hyperglycemia, hyperinsulinemia, and glucose intolerance, was observed in high-fat-fed offspring perinatally exposed to 50 μg/kg · d BPA. No adverse effect of perinatal BPA exposure at 250 and 1250 μg/kg · d was observed no matter on a normal diet or a high-fat diet. These results suggest that perinatal exposure to BPA at reference dose, but not at high dose, impairs glucose tolerance in adult rat offspring on a normal diet and predisposes offspring to metabolic syndrome at adult on a high-fat diet. High-fat diet intake is a trigger that initiates adverse metabolic effects of BPA. |
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Authors:
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Jie Wei; Yi Lin; Yuanyuan Li; Chenjiang Ying; Jun Chen; Liqiong Song; Zhao Zhou; Ziquan Lv; Wei Xia; Xi Chen; Shunqing Xu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-17 |
Journal Detail:
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Title: Endocrinology Volume: 152 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-25 Completed Date: 2011-09-21 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 3049-61 Citation Subset: AIM; IM |
Affiliation:
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Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Body Weight / drug effects Dietary Fats / administration & dosage* Energy Intake Female Fetus / drug effects* Glucose / metabolism Homeostasis Insulin-Secreting Cells / drug effects, pathology, physiology Leptin / blood Lipid Metabolism / drug effects Male Metabolic Syndrome X / chemically induced* Mitochondria / drug effects Phenols / toxicity* Pregnancy Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Leptin; 0/Phenols; 50-99-7/Glucose; 80-05-7/bisphenol A |
| Comments/Corrections | |
Comment In:
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Endocrinology. 2011 Sep;152(9):3301-3
[PMID:
21862570
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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