| Perinatal events and early magnetic resonance imaging in therapeutic hypothermia. | |
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MedLine Citation:
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PMID: 20965514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the association between perinatal events and the pattern and extent of brain injury on early magnetic resonance imaging in newborn infants with and without therapeutic hypothermia for hypoxic-ischemic encephalopathy. STUDY DESIGN: We performed a cohort study of 35 treated and 25 nontreated neonates who underwent magnetic resonance imaging. The injury patterns were defined a priori as: normal, watershed, or basal ganglia/thalamus-predominant, as well as a dichotomous outcome of moderate-to-severe versus mild-no injury. RESULTS: Neonates with hypothermia had less extensive watershed and basal ganglia/thalamus injuries and a greater proportion had normal imaging. Therapeutic hypothermia was associated with a decreased risk of both basal ganglia/thalamus injury (relative risk, 0.29; 95% CI, 0.10 to 0.81, P = .01) and moderate-severe injury. Neonates with sentinel events showed a decrease in basal ganglia/thalamus-predominant injury and an increase in normal imaging. All neonates with decreased fetal movements had injury, predominantly watershed, regardless of therapeutic hypothermia. CONCLUSIONS: These results validate reports of reduced brain injury after therapeutic hypothermia and suggest that perinatal factors are important indicators of response to treatment. |
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Authors:
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Sonia L Bonifacio; Hannah C Glass; Juliana Vanderpluym; Ashish T Agrawal; Duan Xu; A James Barkovich; Donna M Ferriero |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-04-05 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 360-5 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Neonatology, University of California San Francisco, School of Medicine, 533 Parnassus Avenue, U585, Box 0748, San Francisco, CA 94143-0748, USA. bonifacios@peds.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hypothermia, Induced* Hypoxia-Ischemia, Brain / pathology*, therapy* Infant, Newborn Logistic Models Magnetic Resonance Imaging* Male Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS066137-02/NS/NINDS NIH HHS; L40 NS060616-03/NS/NINDS NIH HHS; P50 NS035902-050001/NS/NINDS NIH HHS; P50 NS035902-12/NS/NINDS NIH HHS; UL1 RR024131-01/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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