Document Detail


Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks' gestation.
MedLine Citation:
PMID:  22033298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the frequency of hypoxic-ischemic encephalopathy (HIE) in preterm infants of 33 to 35 weeks' gestational age on the basis of physiological screening for perinatal acidosis and neurological assessment of encephalopathy and to correlate neurodevelopmental outcomes with brain magnetic resonance imaging findings.
STUDY DESIGN: This retrospective cohort study included all inborn infants of 33 to 35 weeks' gestation admitted to the neonatal intensive care unit at Parkland Memorial Hospital with perinatal acidosis from October 2005 to September 2008. Their medical records were reviewed, and pertinent data were recorded.
RESULTS: Of 1305 newborns, 2.5% (n=33) had perinatal acidosis, and 27% (n=9) of these had HIE (2, mild; 4, moderate; 3, severe). Persistence of metabolic acidosis on the first arterial blood gas obtained in the first hour of age was significantly associated with HIE (P<.005). Magnetic resonance imaging results were abnormal in 3 of 4 infants with moderate HIE and in both survivors with severe HIE. Death or disability occurred in no infants with mild or moderate HIE, but in all infants with severe HIE.
CONCLUSION: Screening criteria for HIE that use biochemical and neurological assessments as performed in term newborns can be applied to preterm infants of 33 to 35 weeks' gestation.
Authors:
Lina F Chalak; Nancy Rollins; Michael C Morriss; Luc P Brion; Roy Heyne; Pablo J Sánchez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-26
Journal Detail:
Title:  The Journal of pediatrics     Volume:  160     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-03-27     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-94     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, USA. lina.chalak@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Acidosis / complications,  diagnosis*
Brain / pathology
Child Development
Female
Gestational Age
Humans
Hypoxia-Ischemia, Brain / complications,  diagnosis*
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / diagnosis*
Magnetic Resonance Imaging
Male
Grant Support
ID/Acronym/Agency:
K23 HD069521/HD/NICHD NIH HHS; KL2RR024983/RR/NCRR NIH HHS; UL1 RR024982/RR/NCRR NIH HHS
Comments/Corrections

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