Document Detail

Perimetric and peri-papillary nerve fibre layer thickness findings in multiple sclerosis.
MedLine Citation:
PMID:  21087363     Owner:  NLM     Status:  In-Data-Review    
Background and purpose:  Several previous studies have employed optical coherence tomography (OCT) of the optic disc and 'white-on-white' automated perimetry to evaluate optic neuritis (ON) associated with multiple sclerosis (MS). This study employed OCT, white-on-white automated perimetry as well as 'blue-on-yellow' automated perimetry to evaluate MS patients with or without episodes of ON. Methods:  The MS group consisted of 56 patients with MS (27 patients with no history of ON in both eyes and 29 patients with at least one ON attack in one or both eyes), whereas the control group consisted of 56 age- and sex-matched healthy subjects. All patients underwent a complete neurological and ophthalmological examination. Peri-papillary retinal nerve fibre layer thickness (RNFLT) was evaluated using OCT. The mean defect and pattern standard deviation for both white-on-white and blue-on-yellow perimetry were also recorded. Results:  RNFLT and perimetric scores were significantly lower in MS group without a history of ON and in the unaffected eyes of MS group with unilateral ON, compared with controls. MS group with more than one ON episodes had significantly compromised blue-on-yellow perimetric indices, compared with patients with one ON episode, whereas respective differences for white-on-white perimetry were not statistically significant. Conclusions:  The significantly lower RNFLT and perimetric scores in MS group patients without ON, compared with control group, may possibly be attributed to sub-clinical episodes of ON or to retrograde degeneration of nerve cells from sub-clinical post-chiasmal lesions. Blue-on-yellow perimetry may be advantageous over white-on-white perimetry in evaluating MS-associated functional defects.
G Kitsos; E T Detorakis; S Papakonstantinou; A P Kyritsis; S H Pelidou
Related Documents :
19335073 - Relationship of metabolic syndrome to chronic periodontitis.
955313 - Immunological status in tuberous sclerosis.
3355633 - Phenytoin loading in chronic alcoholic patients.
Publication Detail:
Type:  Journal Article     Date:  2010-11-19
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  18     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  719-25     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
Department of Ophthalmology, Medical School, University of Ioannina, Ioannina Department of Ophthalmology, Medical School, University of Crete, Heraklion Department of Neurology, Medical School, University of Ioannina, Ioannina, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low frequency stimulation of the nucleus tegmenti pedunculopontini increases cortical metabolism in ...
Next Document:  Evaluation of nurse-led discharge following laparoscopic surgery.