Document Detail


Perimetric measurements with flicker defined form stimulation in comparison to conventional perimetry and retinal nerve fiber measurements.
MedLine Citation:
PMID:  24355823     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose: To compare the results of Flicker Defined Form (FDF)-perimetry with standard automated perimetry (SAP) and retinal nerve-fiber-layer (RNFL) thickness measurements using spectral domain OCT. Methods: 64 healthy subjects, 45 ocular hypertensive patients, and 97 'early' open-angle glaucoma (OAG) patients participated in this study. Definition of glaucoma was exclusively based on glaucomatous optic disc appearance. All subjects underwent FDF-perimetry, SAP and peripapillar measurements of the RNFL thickness. FDF-perimetry and SAP were performed at identical test locations (G1 protocol). Exclusion criteria were: subjects younger than 34 years, SAP-MD > 5 dB, eye diseases other than glaucoma, or non-reliable FDF-measurements. The correlations between the perimetric data on the one hand and RNFL thicknesses on the other hand were statistically analyzed. Results: The age corrected sensitivity values and the local results from the controls were used to determine FDF mean-defect (FDF-MD). FDF-perimetry and SAP showed high concordance in this cohort of experienced patients (MD-values: R=-0.69, P <0.001). 38 of in total 42 OAG-patients with abnormal SAP-MD also displayed abnormal FDF-MD. However, FDF-MD was abnormal in 28 out of 55 OAG-patients with normal SAP-MD. FDF-MD was significantly (R=-0.61, P <0.001) correlated with RNFL-thickness with a (non-significantly) larger correlation coefficient than conventional SAP-MD (R=-0.48, P <0.001). Conclusion: FDF-perimetry is able to uncover functional changes concurrent with the changes in RNFL thickness. FDF-perimetry may be an efficient functional test to detect early glaucomatous nerve atrophy.
Authors:
Folkert K Horn; Ralf P Tornow; Anselm G Juenemann; Robert Laemmer; Jan Kremers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-19
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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