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Perimesencephalic subarachnoid hemorrhage: incidence, risk factors, and outcome.
MedLine Citation:
PMID:  16518463     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nonaneurysmal perimesencephalic subarachnoid hemorrhage (PMSAH) appears to have an etiology and natural history distinct from aneurysm rupture. Referral-based studies suggest that 15% of SAH patients have no discernable cause of bleeding, but the incidence of PMSAH is unknown. We describe the first population-based study of PMSAH and place it in the context of all non-traumatic SAH, with presentation of incidence rates, patient demographics, and clinical outcomes.
METHODS: All patients age >/= 18 hospitalized with first-ever, non-traumatic SAH in the Greater Cincinnati area were identified from 5/98-7/01 and 8/02-4/04. PMSAH was defined as hemorrhage restricted to the cisterns surrounding the brainstem and suprasellar cistern and a negative cerebral angiogram. Incidence rates were age, race, and sex adjusted to the 2000 US population.
RESULTS: There were 431 SAHs identified. Cases in Asian-Americans (2) were excluded, leaving 429 SAHs for analysis. Of these patients, 77 did not have angiograms. Among remaining cases, 285 had aneurysm rupture, 43 had nonaneurysmal hemorrhage not of the PMSAH pattern, and 24 had PMSAH. The overall annual incidence rates for SAH and PMSAH were 8.7 (95% CI 7.9-9.5) and 0.5 (95% CI 0.3-0.7) per 100,000 persons age >/= 18. Patients with PMSAH were younger (p = 0.018) and less likely to be female (p = 0.020) or hypertensive (p = 0.005) than other SAH patients. There was one death among PMSAH patients during 14 months mean follow-up.
CONCLUSIONS: PMSAH represents approximately 5% of all SAH. Its risk factors and outcome differ from other forms of SAH.
Authors:
Matthew L Flaherty; Mary Haverbusch; Brett Kissela; Dawn Kleindorfer; Alexander Schneider; Padmini Sekar; Charles J Moomaw; Laura Sauerbeck; Joseph P Broderick; Daniel Woo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  14     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-04-16     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  -    
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Grant Support
ID/Acronym/Agency:
R01 NS036695/NS/NINDS NIH HHS; R01 NS036695-03/NS/NINDS NIH HHS; R01 NS036695-04/NS/NINDS NIH HHS; R01 NS036695-05A2/NS/NINDS NIH HHS; R01 NS036695-06/NS/NINDS NIH HHS; R01 NS036695-07/NS/NINDS NIH HHS; R01 NS036695-08/NS/NINDS NIH HHS
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