| Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. | |
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MedLine Citation:
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PMID: 10805968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perillyl alcohol (POH) inhibits isoprenylation and has shown anticancer and chemopreventive properties in rodent models. The mechanism that underlies the anticancer activity of POH and other isoprenylation inhibitors is unknown but has been postulated to involve decreased levels of isoprenylated Ras and Ras-related proteins. Previously we demonstrated that POH effectively inhibits human T cell proliferation in vitro and can prevent acute and chronic rejection in a rat cardiac transplant model. In this report, we investigate the effects of POH on T lymphocytes at the single-cell level. POH disrupts the polarized shape and motility of antigen-specific murine 1E5 T cells. Using an optical trap to position anti-CD3-coated beads in contact with 1E5 T cells, we demonstrate that POH inhibits their TCR-mediated calcium response. Furthermore, we show that POH preferentially induces apoptosis in PHA-activated human T cells as well as in 1E5 T cells. |
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Authors:
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X Wei; M S Si; D K Imagawa; P Ji; B J Tromberg; M D Cahalan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cellular immunology Volume: 201 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-07-06 Completed Date: 2000-07-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6-13 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Department of Physiology and Biophysics, University of California, Irvine, California, 92697, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkyl and Aryl Transferases / antagonists & inhibitors* Animals Apoptosis / drug effects* Calcium / metabolism* Cell Movement / drug effects* Cell Polarity / drug effects Cell Size / drug effects Enzyme Inhibitors / pharmacology* Humans Mice Monoterpenes* Receptors, Antigen, T-Cell / metabolism* Signal Transduction / physiology* T-Lymphocytes / drug effects*, metabolism, physiology Terpenes / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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GM41514/GM/NIGMS NIH HHS; RR01192/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Monoterpenes; 0/Receptors, Antigen, T-Cell; 0/Terpenes; 536-59-4/perilla alcohol; 7440-70-2/Calcium; EC 2.5.-/Alkyl and Aryl Transferases; EC 2.5.1.-/geranylgeranyltransferase type-I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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