Document Detail


Perifornical fiber system mediates VMH electrically-induced suppression of feeding.
MedLine Citation:
PMID:  7146124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fiber pathways mediating the cessation of food ingestion during continuous low-level electrical stimulation of the ventromedial region of the hypothalamus (VMH) were appraised in food-deprived male rats using knife cuts. Parasagittal knife cuts in the medial perifornical area of the hypothalamus produced much larger increases in threshold current intensities for the inhibition of feeding than did cuts in the lateral perifornical hypothalamus. These findings indicate that fiber pathways critical to the inhibitory feeding effect of continuous VMH electrical stimulation traverse the perifornical hypothalamus but not the lateral hypothalamus. A comparison of these and other results demonstrates an anatomical similarity between the fiber pathways mediating VMH electrically-induced inhibition of feeding and hypothalamic hyperphagia following lesions or knife cuts. The nature of the inhibitory feeding effect of VMH electrical stimulation is also addressed and behavioral observations strongly supportive of a specific anorectic effect produced by the stimulation are reported.
Authors:
P F Aravich; B M Beltt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  29     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Dominance, Cerebral / physiology
Eating*
Electric Stimulation
Hypothalamus / physiology*
Hypothalamus, Posterior / physiology*
Male
Mesencephalon / physiology*
Nerve Fibers / physiology*
Neural Inhibition
Neural Pathways / physiology
Paraventricular Hypothalamic Nucleus / physiology
Rats
Rats, Inbred Strains
Satiety Response / physiology
Ventromedial Hypothalamic Nucleus / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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