Document Detail

Perifollicular vascularity in poor ovarian responders during IVF.
MedLine Citation:
PMID:  16488903     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Normal ovarian responders who have follicles with good vascularity shown by power Doppler scanning are associated with a better pregnancy rate following IVF treatment. This study evaluated the significance of perifollicular vascularity and follicular fluid hormonal profile in poor responders who developed < or = 3 dominant follicles. METHODS: Before oocyte retrieval, they underwent power Doppler examination for perifollicular vascularity. Patients who had all follicles with low-grade vascularity were classified as Group A, whereas those with at least one follicle with high-grade vascularity were Group B. Their follicular fluid concentrations of estradiol (E2), progesterone, HCG, vascular endothelial growth factor (VEGF) and inhibin B were measured. RESULTS: A total of 58 consecutive patients were recruited: 38 in Group A and 20 in Group B. Implantation rate, clinical pregnancy rate and follicular fluid hormonal concentrations were comparable for Groups A and B. Multiple pregnancy and live birth rates appeared higher, whereas miscarriage rate were lower in Group B than Group A, but these differences did not reach statistical significance. CONCLUSION: There were no significant differences in the implantation, clinical pregnancy and live birth rates among poor responders with and without high-grade perifollicular vascularity.
Anita Kan; Ernest Hung Yu Ng; William Shu Biu Yeung; Pak Chung Ho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-17
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1539-44     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, People's Republic of China.
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MeSH Terms
Abortion, Spontaneous
Estradiol / metabolism
Fertilization in Vitro / methods*
Follicular Fluid
Inhibins / metabolism
Ovarian Follicle / blood supply,  pathology*
Ovary / blood supply,  pathology*
Pregnancy, Multiple
Progesterone / metabolism
Vascular Endothelial Growth Factor A / metabolism
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 0/inhibin B; 50-28-2/Estradiol; 57-83-0/Progesterone; 57285-09-3/Inhibins

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