Document Detail


Periepicardial fibrinolytic activity: relation to cardiac bleeding.
MedLine Citation:
PMID:  1154266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of various combinations of streptokinase-induced hyperfibrinolysis, electric shock, myocardial ischemia, and ventricular fibrillation on cat pericardial and epcardial fibrinolytic activity were studied. Streptokinase alone or electric shock alone slightly increased the periepicardial fibrinolytic activity but epicardial rebleeding did not occur. However, streptokinase infusions followed by electric shock and/or myocardial ischemia and/or ventricular fibrillation significantly incrased the periepicardial fibrinolytic activity and rebleeding of the epicardium occurred. Topical application of the fibrinolytic inhibitor epsilonaminocaproic acid (EACA) prevented the epicardial rebleeding.
Authors:
G R Rhodes; D Silver
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  78     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-07     Completed Date:  1975-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aminocaproic Acids / administration & dosage,  pharmacology
Animals
Blood Coagulation / drug effects
Blood Coagulation Tests
Cardiac Surgical Procedures*
Cardiopulmonary Bypass
Cats
Electric Stimulation
Fibrin / analysis,  metabolism
Fibrinogen / administration & dosage,  pharmacology
Fibrinolysis* / drug effects
Heart Diseases*
Hemorrhage*
Injections, Intravenous
Ischemia / chemically induced,  metabolism
Pericardium
Postoperative Complications
Streptokinase / administration & dosage,  pharmacology
Ventricular Fibrillation / metabolism
Chemical
Reg. No./Substance:
0/Aminocaproic Acids; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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