Document Detail

Periconceptional nutrient intakes and risks of neural tube defects in California.
MedLine Citation:
PMID:  20740594     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study investigated the association of neural tube defects (NTDs) with maternal periconceptional intake of folic acid-containing supplements and dietary nutrients, including folate, among deliveries that occurred after folic acid fortification in selected California counties.
METHODS: The population-based case-control study included fetuses and live born infants with spina bifida (189) or anencephaly (141) and 625 nonmalformed, live born controls delivered from 1999 to 2003. Mothers reported supplement use during telephone interviews, which included a 107-item food frequency questionnaire. For dietary nutrients, intakes <25th, 25th to <75th (reference), and > or =75th percentile were compared, based on control distributions.
RESULTS: After adjustment for potential confounders, any versus no supplement intake resulted in ORs of 0.8 (95% CI, 0.5-1.3) for anencephaly and 0.8 (95% CI, 0.6-1.2) for spina bifida. After stratification by maternal intake of vitamin supplements, most factors in the glycemic pathway were not associated with either NTD, with the exception of low levels of fructose and glucose that were significantly associated with anencephaly. Some nutrients that contribute to one-carbon metabolism showed lowered risks (folate, riboflavin, vitamins B(6) and B(12)); others did not (choline, methionine, zinc). Antioxidant nutrients tended to be associated with lowered risks (vitamins C, E, A, beta-carotene, lutein).
CONCLUSIONS: Mothers' intake of vitamin supplements was modestly if at all associated with a lowered risk of NTDs. Dietary intake of several nutrients contributing to one-carbon metabolism and oxidative stress were associated with reduced NTD risk.
Suzan L Carmichael; Wei Yang; Gary M Shaw
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  88     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2010-12-17     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  670-8     Citation Subset:  IM    
California Research Division, March of Dimes Foundation, Oakland, California 94609-1673, USA.
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MeSH Terms
Antioxidants / administration & dosage
California / epidemiology
Carbon / metabolism
Case-Control Studies
Dietary Supplements*
Energy Intake
Folic Acid / administration & dosage*
Fructose / analysis
Glucose / analysis
Neural Tube Defects / epidemiology*,  prevention & control
Young Adult
Grant Support
Reg. No./Substance:
0/Antioxidants; 30237-26-4/Fructose; 50-99-7/Glucose; 59-30-3/Folic Acid; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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