Document Detail

Periconceptional nutrient intake and risk for neural tube defect-affected pregnancies.
MedLine Citation:
PMID:  10535785     Owner:  NLM     Status:  MEDLINE    
We investigated whether intakes of nutrients, including folate, by women in the periconceptional period were associated with risks of neural tube defect (NTD)-affected pregnancies. Data were part of a case-control study of fetuses and infants with NTDs among 1989-1991 California births. We conducted interviews with mothers of 409 NTD cases and 420 nonmal-formed controls. Nutrient intake for the 3 months before conception was derived from food frequency questionnaires and from questions to mothers about vitamin/mineral supplement use. We computed NTD risk for each nutrient controlling for the influence of all other studied nutrients and for maternal education, race/ethnicity, height, and prepregnancy weight. Most single nutrients reduced NTD risks when intakes were considered in quartiles and unadjusted for other nutrients. Some of the same nutrients, however, did not provide similar interpretations when we adjusted for other nutrients. Adjusted analyses revealed decreased NTD risks with increased intakes of methionine, lutein, magnesium, zinc, and thiamin for women who did not use vitamin supplements periconceptionally. We observed decreased NTD risks associated with increased intakes of linoleic acid, cysteine, calcium, and zinc for women who used supplements. We also observed increased NTD risks with increased intakes of oleic acid. For users as well as nonusers of vitamin supplements, we observed reduced risks with increased intakes of grains and dairy products. Chance was a likely alternative explanation for many of the observed risk patterns.
G M Shaw; K Todoroff; D M Schaffer; S Selvin
Related Documents :
7730885 - Vitamin supplementation and reduced risk of basal cell carcinoma.
19027405 - Socioeconomic differences in fruit and vegetable consumption among middle-aged french a...
19601865 - Vitamin d and cardiovascular disease.
15238285 - Nutritional factors and susceptibility to arsenic-caused skin lesions in west bengal, i...
21843835 - Foot orthoses can reduce lower limb overuse injury rate.
19028385 - Sexual function in women with female genital mutilation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  10     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-19     Completed Date:  1999-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  711-6     Citation Subset:  IM    
March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville 94608, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
California / epidemiology
Dietary Supplements*
Neural Tube Defects / epidemiology*
Nutritional Status*
Retrospective Studies
Risk Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Two centuries of mortality in ten large families with Huntington disease: a rising impact of gene ca...
Next Document:  A low pregnancy body mass index is a risk factor for an offspring with gastroschisis.