| Periconceptional multivitamin use reduces the risk of preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 16772374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective was to assess the independent effect of regular periconceptional multivitamin use on the risk of preeclampsia. Pregnant women (n=1,835) enrolled in the Pregnancy Exposures and Preeclampsia Prevention Study (Pittsburgh, Pennsylvania, 1997-2001) at less than 16 weeks' gestation were asked whether they regularly used multivitamins or prenatal vitamins in the past 6 months. Women were classified as users or nonusers. The unadjusted prevalence of preeclampsia was 4.4% in nonusers and 3.8% in users. After adjustment for race/ethnicity, marital status, parity, prepregnancy physical activity, and income in a multiple logistic regression model, regular use of multivitamins was associated with a 45% reduction in preeclampsia risk compared with nonuse (odds ratio (OR)=0.55, 95% confidence interval (CI): 0.32, 0.95). Prepregnancy overweight modified this effect. After confounder adjustment, lean multivitamin users had a 71% reduction in preeclampsia risk compared with lean nonusers (OR=0.29, 95% CI: 0.12, 0.65). In contrast, there was no relation between multivitamin use and preeclampsia among overweight women (OR=1.08, 95% CI: 0.52, 2.25). A sensitivity analysis for unmeasured confounding by fruit and vegetable intake supported these conclusions. If confirmed by others, these results suggest that regular use of a multivitamin supplement in the periconceptional period may help to prevent preeclampsia, particularly among lean women. |
| | |
Authors:
|
Lisa M Bodnar; Gong Tang; Roberta B Ness; Gail Harger; James M Roberts |
Related Documents
:
|
19049844 - Haemostatic factors in women with history of preeclampsia. 9746654 - Prelabor rupture of membranes at term: induce or wait? 20562184 - Circulating 25-hydroxyvitamin d and risk of non-hodgkin lymphoma: cohort consortium vit... 19228854 - Preeclampsia-eclampsia and the risk of stroke among peripartum in taiwan. 15671704 - The impact of environmental tobacco smoke on women's risk of dying from heart disease: ... 1793104 - Evaluation of selection bias in a cross-sectional survey. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-06-13 |
Journal Detail:
|
Title: American journal of epidemiology Volume: 164 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-23 Completed Date: 2006-09-28 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
|
Languages: eng Pagination: 470-7 Citation Subset: IM |
Affiliation:
|
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA. bodnar@edc.pitt.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Body Weight Dietary Supplements* Female Humans Maternal Nutritional Physiological Phenomena* Pre-Eclampsia / prevention & control* Pregnancy Risk Vitamins / administration & dosage, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
|
5M01 RR00056/RR/NCRR NIH HHS; K12 HD43441/HD/NICHD NIH HHS; PPG 2P01 HD30367/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessing the completeness of reporting of human immunodeficiency virus diagnoses in 2002-2003: capt...
Next Document: A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding prote...