Document Detail

Periconceptional maternal vitamin supplementation and childhood leukaemia: an uncertainty analysis.
MedLine Citation:
PMID:  18977808     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies in childhood cancer suggest that maternal vitamin supplementation may reduce the risk of leukaemia, neuroblastoma and certain types of childhood brain tumours. For example, a previous study found a significantly reduced risk of acute lymphoblastic leukaemia (ALL) but not acute myeloid leukaemia (AML) in children with Down syndrome whose mothers reported any vitamin supplement use prior to knowledge of pregnancy (ALL OR adjusted for confounders 0.51, 95% confidence limits (CL): 0.30, 0.89; AML OR adjusted for confounders 0.92, 95% CL 0.48, 1.76). Recall of exposures, including maternal vitamin supplement use, however, may be difficult and subject to error. Epidemiologists are encouraged to quantitatively adjust for systematic error in study results, but often do not.
METHODS: The impact that misclassification of maternal vitamin supplement use may have had on the observed ORs in this study was quantified. Uncertainty analysis was used to calculate ORs adjusted for inaccurate reporting of vitamin supplement use under assumed probability distributions for exposure misclassification parameters.
RESULTS: Given our assumptions, adjustment for exposure misclassification yielded ORs that were predominantly more protective for ALL than the crude OR.
CONCLUSIONS: Uncertainty analysis can give important insights into the magnitude and direction of error in study results due to exposure misclassification.
A M Jurek; G Maldonado; L G Spector; J A Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-31
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  63     ISSN:  1470-2738     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-12-15     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  IM    
University of Minnesota, Department of Pediatrics, Mayo Mail Code 715, 420 Delaware St. SE, Minneapolis, MN 55455, USA.
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MeSH Terms
Bias (Epidemiology)
Dietary Supplements / utilization*
Down Syndrome / complications,  epidemiology
Mental Recall
Preconception Care / methods*,  statistics & numerical data
Precursor Cell Lymphoblastic Leukemia-Lymphoma / embryology,  epidemiology,  etiology,  prevention & control*
Prenatal Exposure Delayed Effects
Vitamins / administration & dosage*
Grant Support
Reg. No./Substance:
Comment In:
J Epidemiol Community Health. 2009 Feb;63(2):91   [PMID:  19141660 ]

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