Document Detail

Periconceptional folic acid supplementation as a social intervention.
MedLine Citation:
PMID:  8560289     Owner:  NLM     Status:  MEDLINE    
Periconceptional folic acid supplementation has been shown to decrease the first occurrence of isolated neural tube defects (NTDs) by as much as 50%, and to decrease the recurrence risk for NTDs by more than 70%. The possible mechanisms of vitamin supplementation in the prevention of NTDs are discussed, as are the current recommendations for reproductive-age women. Further, the limitations of dietary and pharmacological recommendations with regard to patient compliance as well as the possibility of grain fortification are reviewed.
N C Rose; M T Mennuti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  19     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-28     Completed Date:  1996-02-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-54     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
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MeSH Terms
Folic Acid / administration & dosage*,  physiology
Neural Tube Defects / embryology,  etiology,  prevention & control*
Reg. No./Substance:
59-30-3/Folic Acid

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