Document Detail

Periconceptional folic acid prevents miscarriage in Irish families with neural tube defects.
MedLine Citation:
PMID:  21052862     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Miscarriages occur to excess in sibships with neural tube defects (NTDs) and among maternal versus paternal relatives in NTD families. Folic acid prevents most NTDs. Its potential to prevent miscarriages has been controversial.
AIM: We evaluated the relationship of maternal line and periconceptional folic acid with miscarriage.
METHODS: First cousins in Irish families with NTDs were interviewed about pregnancy outcomes and the health of their offspring.
RESULTS: Miscarriages were not more frequent among pregnancies of maternal versus paternal first cousins. Folic acid intake during early pregnancy significantly reduced the risk of miscarriage from 15.7 to 9.6%, for an adjusted odds ratio of 0.37 (95% confidence interval 0.19, 0.72, p = 0.005).
CONCLUSIONS: Folic acid during pregnancy was associated with a reduction of approximately 60% in miscarriages. Miscarriages are common-one in every eight pregnancies in this study. If incorporated into pre-pregnancy counseling, these results could have significant public health impact.
J Byrne
Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  Irish journal of medical science     Volume:  180     ISSN:  1863-4362     ISO Abbreviation:  Ir J Med Sci     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Boyne Research Institute, Duke House, Duke Street, Drogheda, Ireland,
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