Document Detail


Periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure and risk for spontaneous abortion.
MedLine Citation:
PMID:  22914399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the association between over-the-counter nonsteroidal anti-inflammatory drug (NSAID) exposure during the early first trimester and risk for spontaneous abortion (gestation before 20 weeks of gestation) in a prospective cohort.
METHODS: Women were enrolled in the Right from the Start study (2004-2010). Exposure data regarding over-the-counter NSAID use from the last menstrual period (LMP) through the sixth week of pregnancy were obtained from intake and first-trimester interviews. Pregnancy outcomes were self-reported and verified by medical records. Gestational age was determined from the LMP. Stage of development before loss was determined from study ultrasonography. Cox proportional hazards regression models were used to estimate the association between NSAID exposure and pregnancy outcome taking into account candidate confounders.
RESULTS: Among 2,780 pregnancies, 367 women (13%) experienced a spontaneous abortion. NSAID exposure was reported by 1,185 (43%) women. NSAID exposure was not associated with spontaneous abortion risk in unadjusted models (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.82-1.24) or models adjusted for maternal age (adjusted HR 1.00, 95% CI 0.81-1.23).
CONCLUSION: Our findings suggest that use of nonprescription over-the-counter NSAIDs in early pregnancy does not put women at increased risk of spontaneous abortion.
Authors:
Digna R Velez Edwards; Tiara Aldridge; Donna D Baird; Michele Jonsson Funk; David A Savitz; Katherine E Hartmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  120     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-23     Completed Date:  2012-11-16     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  AIM; IM    
Affiliation:
Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Department of Obstetrics and Gynecology, and the Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA. digna.r.velez.edwards@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / chemically induced,  epidemiology*,  ultrasonography
Adult
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects*
Female
Gestational Age
Humans
Nonprescription Drugs / administration & dosage,  adverse effects*
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, First / drug effects
Proportional Hazards Models
Prospective Studies
Risk
Ultrasonography, Prenatal
Grant Support
ID/Acronym/Agency:
K02HS017950/HS/AHRQ HHS; K12 HD043483/HD/NICHD NIH HHS; K12HD4383/HD/NICHD NIH HHS; KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; R01 HD043883/HD/NICHD NIH HHS; R01 HD049675/HD/NICHD NIH HHS; R01HD043883/HD/NICHD NIH HHS; R01HD049675/HD/NICHD NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975-01/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Nonprescription Drugs
Comments/Corrections

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