Document Detail

Pericentric inversion of chromosome 16 and eosinophilia in chronic myelomonocytic leukemia.
MedLine Citation:
PMID:  9109936     Owner:  NLM     Status:  MEDLINE    
We report a case of myelodysplastic syndrome with bone marrow eosinophilia and the chromosomal abnormality, inv(16)(p13q22). Hematologic findings including monocytosis and trilineage myelodysplasia were consistent with chronic myelomonocytic leukemia, and numerous abnormal eosinophils were present in the bone marrow. Chromosomal analysis of all metaphase cells from peripheral blood and bone marrow revealed in(16)(p13q22), which is well known characteristic of acute myelomonocytic leukemia with eosinophilia (M4Eo). Both monocytes and eosinophils in this case may be derived from common leukemic progenitors affected by inv(16)(p13q22).
T Miyamoto; K Akashi; S Hayashi; A Oogami; T Okamura; H Iwasaki; M Murakawa; M Harada; Y Niho
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  94     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-01     Completed Date:  1997-05-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Department of Hematology, Harasanshin General Hospital, Fukuoka, Japan.
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MeSH Terms
Chromosome Aberrations / pathology*
Chromosome Banding
Chromosome Disorders
Chromosome Inversion
Chromosomes, Human, Pair 16*
Eosinophilia / genetics*
Leukemia, Myelomonocytic, Chronic / genetics*,  pathology
Comment In:
Cancer Genet Cytogenet. 1998 Feb;101(1):81   [PMID:  9460508 ]

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