Document Detail


Pericentric chromosome 8 inversion associated with the 5'RUNX1/3'CBFA2T1 gene in acute myeloid leukemia cases.
MedLine Citation:
PMID:  15551097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present paper we report pericentric chromosome 8 inversions in two (2.4%) of 82 acute myeloid leukemia (AML) cases characterized by the 5'RUNX1/3'CBFA2T1 fusion gene. Molecular cytogenetic characterization was achieved using appropriate bacterial artificial chromosome (BAC) and P1 artificial chromosome (PAC) probes in fluorescence in situ hybridization (FISH) experiments. In these two cases the fusion gene was detected on the der(8) short arm, resulting from a pericentric chromosome 8 inversion followed by a t(8;21) rearrangement. These results suggest that heterogeneous mechanisms can lead to the generation of the 5'RUNX1/3'CBFA2T1chimeric gene.
Authors:
L Anelli; F Albano; A Zagaria; A Liso; A Cuneo; M Mancini; V Liso; M Rocchi; G Specchia
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-16
Journal Detail:
Title:  Annals of hematology     Volume:  84     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-09     Completed Date:  2005-05-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Department of Hematology, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Chromosome Inversion*
Chromosomes, Human, Pair 8*
Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins / genetics*
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myeloid / genetics*
Male
Middle Aged
Oncogene Proteins, Fusion / genetics
Proto-Oncogene Proteins / genetics*
Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/Core Binding Factor Alpha 2 Subunit; 0/DNA-Binding Proteins; 0/Oncogene Proteins, Fusion; 0/Proto-Oncogene Proteins; 0/RUNX1 protein, human; 0/RUNX1T1 protein, human; 0/Transcription Factors

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