Document Detail

Pericardial, retroperitoneal, and pleural fibrosis induced by pergolide.
MedLine Citation:
PMID:  9886458     Owner:  NLM     Status:  MEDLINE    
Three patients with Parkinson's disease are described who developed pericardial, retroperitoneal, and pleural fibrosis associated with pergolide treatment. Surgical intervention was required in all three cases, either to reach a tissue diagnosis or for potentially life threatening complications. Symptoms emerged on average 2 years after the institution of treatment, and were sufficiently non-specific to cause significant delays in diagnosis in all cases. The erythrocyte sedimentation rate (ESR) was raised in the two patients in whom it was measured. Serosal fibrosis is a rarely reported adverse effect of pergolide treatment, although it is well described with other dopamine agonists. We suggest that patients with Parkinson's disease who receive pergolide treatment should be regularly monitored for the development of such complications.
S Shaunak; A Wilkins; J B Pilling; D J Dick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  66     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  79-81     Citation Subset:  IM    
Department of Neurology, Norfolk and Norwich Hospital, UK.
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MeSH Terms
Antiparkinson Agents / adverse effects*
Fibrosis / chemically induced,  pathology
Middle Aged
Parkinson Disease / drug therapy
Pergolide / adverse effects*
Pericardium / pathology*
Pleura / pathology*
Retroperitoneal Fibrosis / chemically induced*
Reg. No./Substance:
0/Antiparkinson Agents; 66104-22-1/Pergolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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