Document Detail


Pericardial effusion causes interstitial pulmonary edema in dogs.
MedLine Citation:
PMID:  3652423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pulmonary effects of pericardial effusion were studied in eight anesthetized dogs, with emphasis on lung mechanics, O2 exchange, and extravascular thermal lung volume (ETV) accumulation, while warm saline was instilled into the pericardium to elevate pericardial pressure. The results were compared with those from four time-controlled and sham-operated dogs. ETV, as measured by a double-indicator technique, increased from 8.1 +/- 0.8 ml/kg at a pericardial pressure of 0 mm Hg to 12.9 +/- 2.1 ml/kg at 11.0 mm Hg (p less than .01). In the control group, ETV increased from 6.5 +/- 0.7 to 8.2 +/- 0.5 ml/kg over an equal time span. This increase in ETV in the experimental dogs was inversely related to pulmonary compliance, which decreased by 29% as ETV increased (p less than .05), whereas in the time-controlled group of animals it decreased by 8.8%. Arterial PO2 did not deteriorate during the protocol in either group. Histologic examination showed increased interstitial fluid, but neither alveolar fluid nor septal edema, and gravimetric measurements of lung liquid were also consistent with interstitial fluid accumulation in experimental but not control animals. These findings are concordant with the clinical observation that alveolar edema is rarely seen in the presence of pericardial tamponade. Conceivably, progression from interstitial to alveolar edema did not occur both because of the low pulmonary blood flow that occurs as part of pericardial tamponade physiology and/or because the hydrostatic pressures were not elevated enough to produce higher rates of fluid transudation.
Authors:
J I Sznajder; E Evander; E R Pollak; C Becker; A G Little
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  76     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  843-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Chicago Hospitals, IL 60637.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Dogs
Extracellular Space / metabolism
Hemodynamics
Lung / metabolism,  pathology,  physiopathology*
Lung Volume Measurements
Pericardial Effusion / complications*,  pathology,  physiopathology
Pulmonary Edema / etiology*,  pathology,  physiopathology
Pulmonary Gas Exchange
Grant Support
ID/Acronym/Agency:
HL 30835/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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