| Pericardial fat amount is an independent risk factor of coronary artery stenosis assessed by multidetector-row computed tomography: the Korean Atherosclerosis Study 2. | |
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MedLine Citation:
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PMID: 20948524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pericardial fat surrounding the heart and coronary arteries might aggravate vessel wall inflammation and stimulate the progression of coronary atherosclerosis. However, there has been little comprehensive evaluation of the effects of pericardial fat on coronary artery disease (CAD). We investigated the relationship between pericardial fat volume and the severity of coronary artery stenosis assessed by computed tomography and angiography among patients with suspected CAD. Participants from the cohort of the Korean Atherosclerosis Study 2 (n = 402, mean age of 54 years, 57.0% men) underwent 64-slice multidetector-row computed tomography (MDCT) to assess pericardial fat amount, coronary artery calcium score (CACS), severity of coronary artery stenosis, and plaque characteristics. Patients with atherosclerotic lesion had significantly larger volume of pericardial fat than patients without atherosclerosis (308 ± 96 cm(3) vs. 251 ± 93 cm(3); P < 0.01). In a multivariate regression analysis adjusting for age, gender and BMI, subjects with more pericardial fat had a higher risk for significant (>50%) stenosed coronary vessels (odds ratio (OR) = 1.012; 95% confidence interval (CI) 1.001-1.030; P = 0.017). This association remained after adjusting for hypertension, diabetes, smoking status, and lipid profiles (OR = 1.007; 95% CI 1.001-1.014; P = 0.042). In conclusion, an increased pericardial fat volume was an independent risk factor for stenotic CAD and could be helpful in assessing subclinical CADs. |
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Authors:
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Tae Hyuk Kim; Sung Hoon Yu; Sung Hee Choi; Ji Won Yoon; Seon Mee Kang; Eun Ju Chun; Sang Il Choi; Hayley Shin; Hong Kyu Lee; Kyong Soo Park; Hak Chul Jang; Soo Lim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-14 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-26 Completed Date: 2012-05-04 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1028-34 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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pathology*,
radiography Asian Continental Ancestry Group / statistics & numerical data Atherosclerosis / pathology, radiography Cohort Studies Coronary Angiography / methods* Female Humans Male Middle Aged Multidetector Computed Tomography / methods* Obesity, Abdominal / pathology, radiography Odds Ratio Pericardium / pathology*, radiography Predictive Value of Tests Prevalence Republic of Korea / epidemiology Risk Factors Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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