Document Detail

Peribulbar anaesthesia with 1% ropivacaine and hyaluronidase 300 IU ml-1: comparison with 0.5% bupivacaine/2% lidocaine and hyaluronidase 50 IU ml-1.
MedLine Citation:
PMID:  11064623     Owner:  NLM     Status:  MEDLINE    
The low toxicity of ropivacaine makes it attractive for peribulbar anaesthesia. However, its motor-sparing properties are undesirable when akinesia is important. Hyaluronidase (300 IU ml-1) promotes the onset and quality of peribulbar blockade when used with other agents. We investigated the onset and quality of ocular akinesia in 80 patients randomized to receive 1% ropivacaine plus hyaluronidase 300 IU ml-1 (group 1), or bupivacaine 0.5%/Lidocaine 2% plus 50 IU ml-1 hyaluronidase (group 2). Ocular akinesia was scored from 0 (no movement) to 8 (full movement) every 2 min for 20 min. The groups showed no difference in the rate of onset or degree of akinesia achieved (analysis of variance with repeated measures; P = 0.34). Sixty per cent of patients in group 1 and 55% in group 2 achieved akinesia scores of < or = 4 by 6 min (chi 2 test; P = 0.5). We conclude that both peribulbar solutions produce equivalent onset and quality of ocular akinesia.
D K Woodward; A T Leung; M W Tse; R W Law; D S Lam; W D Ngan Kee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-09     Completed Date:  2000-11-09     Revised Date:  2007-04-26    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  618-20     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China.
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MeSH Terms
Amides / pharmacology*
Anesthesia, Local / methods
Anesthetics, Combined / pharmacology
Anesthetics, Local / pharmacology*
Bupivacaine / pharmacology
Double-Blind Method
Eye Movements / drug effects*
Hyaluronoglucosaminidase / pharmacology*
Lidocaine / pharmacology
Reg. No./Substance:
0/Amides; 0/Anesthetics, Combined; 0/Anesthetics, Local; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine; 84057-95-4/ropivacaine; EC

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