| Perianal Paget's disease-Report of a rare case. | |
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MedLine Citation:
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PMID: 22796514 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Perianal extra-mammary Paget's disease is a rare skin disorder of unknown aetiology, which is frequently associated with malignancy. This case report draws attention to this rare condition and comments upon its diagnosis and treatment. PRESENTATION OF CASE: A 64-year-old otherwise fit man, presented to us in 2006 with one-year-long history of perianal irritation. On examination there was an erythematous discoid skin lesion in the right perianal area. The lesion was excised with wide margins and the defect closed with a local transposition flap. Histology confirmed extra-mammary Paget's disease (EMPD) with a focus of invasion showing a well-differentiated mucinous adenocarcinoma. Adjuvant therapy was not advised. On follow-up in 2011, a small irregular skin lesion, well away from the previous excision site was noted on the left perianal area. Biopsies from this lesion confirmed EMPD with no focus of invasion. Once again wide local excision with closure using local transposition flap was undertaken. Long term follow up has been advised. DISCUSSION: The optimal treatment for Perianal Paget's disease (PPD) remains controversial. Surgery is the commonest modality used with wide local excision being the treatment of choice for resectable disease. We report herein a short review of various therapies reported so far in the management of this rare disorder. CONCLUSION: A thorough initial evaluation and long-term follow-up is essential to identify recurrence and the development of other related malignancies. |
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Authors:
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Maria Stavrou; Laura Martin; Faisal El-Madani; Veena Naik; Stephanos Papanastasiou; Sanjay Gupta |
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Publication Detail:
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Type: Journal Article Date: 2012-06-13 |
Journal Detail:
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Title: International journal of surgery case reports Volume: 3 ISSN: 2210-2612 ISO Abbreviation: Int J Surg Case Rep Publication Date: 2012 |
Date Detail:
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Created Date: 2012-08-20 Completed Date: 2012-10-02 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 101529872 Medline TA: Int J Surg Case Rep Country: Netherlands |
Other Details:
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Languages: eng Pagination: 483-5 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Lister Hospital, Coreys Mill Lane, Stevenage SG1 4AB, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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