Document Detail


Peri-operative use of dexmedetomidine in airway reconstruction surgery for obstructive sleep apnoea.
MedLine Citation:
PMID:  19852868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the peri-operative usefulness of dexmedetomidine in obstructive sleep apnoea surgery. METHODS: In a clinical audit, patients were divided into a study group (dexmedetomidine used; n = 125; 82.9 per cent males, 17.1 per cent females; mean age 48.1 years) and a control group (dexmedetomidine not used; n = 143; 85.5 per cent males, 14.5 per cent females; mean age 47.4 years). The selected outcome measures were mean arterial pressure, use of anti-hypertensives and use of opioids. RESULTS: Mean arterial pressure was stable (i.e. below 100 mmHg) in 93.3 per cent of the study group and 72.0 per cent of the control group (relative risk 1.30, 95 per cent confidence interval 1.14-1.47). The use of glyceryl trinitrate and hydralazine was significantly less in the study group, compared with controls (p = 0.005 and <0.001, respectively). Study group patients underwent more procedures than control patients (p < 0.001) and were more likely to require morphine. No difference was noted in the median dose of opioids. CONCLUSION: Dexmedetomidine improves haemodynamic stability in patients undergoing surgery for obstructive sleep apnoea. It is reliable and reduces the need for polypharmacy. Its opioid-sparing action has been established in the literature; however, this was not demonstrated in our study.
Authors:
S Chawla; S Robinson; A Norton; A Esterman; T Taneerananon
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Publication Detail:
Type:  Journal Article     Date:  2009-10-26
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  124     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-06     Completed Date:  2010-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  AIM; IM    
Affiliation:
Department of ENT, Head and Neck Surgery, Flinders Medical Centre, Adelaide, Australia. sharadch@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, General / methods*
Blood Pressure
Case-Control Studies
Dexmedetomidine / therapeutic use*
Female
Humans
Hypnotics and Sedatives / therapeutic use*
Male
Middle Aged
Otorhinolaryngologic Surgical Procedures / methods
Perioperative Care
Sleep Apnea, Obstructive / physiopathology,  surgery*
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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