Document Detail


Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep.
MedLine Citation:
PMID:  15078864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An adverse environment around conception and implantation influences later fetal growth and development to term in humans and sheep. Indeed, preimplantation undernutrition of rats elevated the systolic blood pressure of the resultant adult offspring. In this study, adult cardiovascular function is examined in a slower growing, non-litter-bearing species after peri-implantation undernutrition. Eight ewes were fed to 50% equivalent food intake of 12 control ewes from 1 to 30 days (term approximately 147 days) only. Following consumption of an adequate diet to term, natural lambing, and then weaning, resting cardiovascular status and baroreflex function were examined in the resultant young adult offspring. Birth weight and postnatal growth to 1 year of age were unaffected by early undernutrition; however, nutrient-restricted sheep had increased pulse pressure, a reduced rate pressure product, and a leftward shift in their baroreflex function curve. Baroreflex sensitivity during angiotensin II infusion was also blunted in early nutrient-restricted sheep but the tachycardia following a reduction in central blood pressure appeared potentiated, relative to controls. The data suggest that peri-implantation undernutrition may program long-term cardiovascular dysfunction that ultimately increases the risk of hypertension later in life. An increase in regional angiotensin II activity during this critical early phase of development is a likely candidate mechanism for the effects observed. The data have broad implications for the health outcome of those offspring from mothers who were poorly nourished during early, often unknown pregnancy and for embryos artificially manipulated because of infertility treatment.
Authors:
David S Gardner; Sarah Pearce; Jennifer Dandrea; Ronald Walker; Margaret M Ramsay; Terence Stephenson; Michael E Symonds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-04-12
Journal Detail:
Title:  Hypertension     Volume:  43     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-10-28     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1290-6     Citation Subset:  IM    
Affiliation:
Center for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, United Kingdom. david.gardner@nottingham.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology*
Animals
Baroreflex / drug effects*
Birth Weight
Blastocyst*
Blood Pressure
Female
Food Deprivation
Hemodynamics / drug effects
Hypertension / etiology*
Hypotension / complications
Malnutrition / physiopathology*
Nitroprusside / pharmacology
Organ Size
Phenylephrine / pharmacology
Pregnancy
Pregnancy Complications / physiopathology*
Prenatal Exposure Delayed Effects*
Reflex, Abnormal / drug effects*
Sheep
Tachycardia / etiology
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine
Comments/Corrections

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