| Peri-OVLT E-series prostaglandins and core temperature do not increase after intravenous IL-1beta in pregnant rats. | |
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MedLine Citation:
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PMID: 12133861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats have an attenuated febrile response to endogenous pyrogen near the term of pregnancy. Given the fundamental role of E-series prostaglandins (PGEs) in mediating the febrile response to blood-borne endogenous pyrogen, the present experiments were carried out to determine whether PGEs increase in the area surrounding the organum vasculosum laminae terminalis (peri-OVLT) of near-term pregnant (P) rats as in nonpregnant (NP) rats after intravenous (iv) administration of recombinant rat interleukin-1beta (rrIL-1beta). Core temperature was measured by telemetry and peri-OVLT interstitial fluid was sampled in 12 NP and 12 P chronically instrumented, Sprague-Dawley rats by microdialysis for determination of total PGEs by radioimmunoassay. Basal core temperatures were higher in NP compared with P rats (NP 37.9 degrees C +/- 0.5, P 36.9 degrees C +/- 0.4; P < 0.05), but basal peri-OVLT PGEs were similar in both groups (NP 260 +/- 153 pg/ml, P 278 +/- 177 pg/ml; P =not significant). Intravenous administration of rrIL-1beta to NP rats produced a significant increase in core temperature with a latency, magnitude, and duration of 10 min, 0.87 degrees C, and at least 170 min, respectively; peri-OVLT PGEs were increased significantly by 30 min and averaged 270% above basal levels throughout the experiment. In P rats, however, neither core temperature nor peri-OVLT PGEs increased significantly after iv administration of rrIL-1beta. Intravenous administration of vehicle did not significantly alter core temperature or peri-OVLT PGEs in either group of rats. Thus peri-OVLT PGEs do not increase in P rats as they do in NP rats after iv administration of rrIL-1beta. The mechanism of this interesting component of the maternal adaptation to pregnancy, which likely plays a major role in mediating the attenuated febrile response to endogenous pyrogen near the term of pregnancy, warrants further investigation. |
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Authors:
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James E Fewell; Heather L Eliason; Roland N Auer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 93 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-22 Completed Date: 2003-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 531-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada T2N 4N1. fewell@ucalgary.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects, immunology* Female Hypothalamus / immunology, metabolism Injections, Intravenous Interleukin-1 / pharmacology* Microdialysis Pregnancy Pregnancy, Animal / immunology* Prostaglandins E / metabolism* Pyrogens / pharmacology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Prostaglandins E; 0/Pyrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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