| Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study. | |
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MedLine Citation:
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PMID: 20639302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Central obesity is associated with peripheral arterial disease, suggesting that ectopic fat depots may be associated with localized diseases of the aorta and lower-extremity arteries. We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index. METHODS AND RESULTS: We quantified periaortic fat surrounding the thoracic aorta using a novel volumetric quantitative approach in 1205 participants from the Framingham Heart Study Offspring cohort (mean age, 65.9 years; women, 54%); visceral abdominal fat also was measured. Clinical peripheral arterial disease was defined as a history of intermittent claudication, and ankle-brachial index was dichotomized as low ( ≤ 0.9) or lower-extremity revascularization versus normal (> 0.9 to < 1.4). Regression models were created to examine the association between periaortic fat and intermittent claudication or low ankle-brachial index (n = 66). In multivariable logistic regression, per 1 SD increase in periaortic fat, the odds ratio for the combined end point was 1.52 (P = 0.004); these results were strengthened with additional adjustment for body mass index (odds ratio, 1.69; P = 0.002) or visceral abdominal fat (odds ratio, 1.67; P = 0.009), whereas no association was observed for visceral abdominal fat (P = 0.16). Similarly, per SD increase in body mass index or waist circumference, no association was observed after accounting for visceral abdominal fat (body mass index, P = 0.35; waist circumference, P=0.49). CONCLUSIONS: Periaortic fat is associated with low ABI and intermittent claudication. |
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Authors:
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Caroline S Fox; Joseph M Massaro; Christopher L Schlett; Sam J Lehman; James B Meigs; Christopher J O'Donnell; Udo Hoffmann; Joanne M Murabito |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-16 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 3 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-10-04 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 515-9 Citation Subset: IM |
Affiliation:
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National Heart, Lung, and Blood Institute Framingham Heart Study, Bethesda, MD, USA. foxca@nhlbi.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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physiopathology*,
radiography Adiposity* Aged Ankle Brachial Index* Aorta, Thoracic Cross-Sectional Studies Female Humans Intermittent Claudication / etiology*, physiopathology, radiography Logistic Models Male Middle Aged Obesity, Abdominal / complications*, physiopathology, radiography Odds Ratio Peripheral Vascular Diseases / etiology*, physiopathology, radiography Risk Assessment Risk Factors Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK080140/DK/NIDDK NIH HHS; M01-RR-01066/RR/NCRR NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS; ZIA HL006094-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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