Document Detail


Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study.
MedLine Citation:
PMID:  20639302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Central obesity is associated with peripheral arterial disease, suggesting that ectopic fat depots may be associated with localized diseases of the aorta and lower-extremity arteries. We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index.
METHODS AND RESULTS: We quantified periaortic fat surrounding the thoracic aorta using a novel volumetric quantitative approach in 1205 participants from the Framingham Heart Study Offspring cohort (mean age, 65.9 years; women, 54%); visceral abdominal fat also was measured. Clinical peripheral arterial disease was defined as a history of intermittent claudication, and ankle-brachial index was dichotomized as low ( ≤ 0.9) or lower-extremity revascularization versus normal (> 0.9 to < 1.4). Regression models were created to examine the association between periaortic fat and intermittent claudication or low ankle-brachial index (n = 66). In multivariable logistic regression, per 1 SD increase in periaortic fat, the odds ratio for the combined end point was 1.52 (P = 0.004); these results were strengthened with additional adjustment for body mass index (odds ratio, 1.69; P = 0.002) or visceral abdominal fat (odds ratio, 1.67; P = 0.009), whereas no association was observed for visceral abdominal fat (P = 0.16). Similarly, per SD increase in body mass index or waist circumference, no association was observed after accounting for visceral abdominal fat (body mass index, P = 0.35; waist circumference, P=0.49).
CONCLUSIONS: Periaortic fat is associated with low ABI and intermittent claudication.
Authors:
Caroline S Fox; Joseph M Massaro; Christopher L Schlett; Sam J Lehman; James B Meigs; Christopher J O'Donnell; Udo Hoffmann; Joanne M Murabito
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-07-16
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  3     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2010-10-04     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / physiopathology*,  radiography
Adiposity*
Aged
Ankle Brachial Index*
Aorta, Thoracic
Cross-Sectional Studies
Female
Humans
Intermittent Claudication / etiology*,  physiopathology,  radiography
Logistic Models
Male
Middle Aged
Obesity, Abdominal / complications*,  physiopathology,  radiography
Odds Ratio
Peripheral Vascular Diseases / etiology*,  physiopathology,  radiography
Risk Assessment
Risk Factors
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
K24 DK080140/DK/NIDDK NIH HHS; M01-RR-01066/RR/NCRR NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS; ZIA HL006094-01/HL/NHLBI NIH HHS
Comments/Corrections

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