| Perfusion-weighted MRI in evaluating the intranodular hemodynamic characteristics of dysplastic nodules and hepatocellular carcinomas in an experimental rat model. | |
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MedLine Citation:
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PMID: 18022847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the value of perfusion-weighted MRI in the evaluation of the intranodular hemodynamic characteristics of dysplastic nodules (DNs) and hepatocellular carcinomas (HCCs) in an experimental rat model. MATERIALS AND METHODS: A total of 40 rats with chemically-induced DNs and HCCs were investigated. Single-slice gadolinium-enhanced perfusion-weighted MRI was performed to evaluate the nodules. Time to peak (Tp), maximal relative signal enhancement (REmax), and the initial slope of signal intensity (SI) vs. time curves of the nodules and cirrhotic liver were evaluated. Nodules precisely corresponding to MRI were examined histologically. Paired Student's t-tests were used to compare the difference between nodules and cirrhotic liver. RESULTS: A total of 20 HCCs and 14 DNs were evaluated. HCCs showed a significantly higher REmax, shorter Tp, and higher slope than adjacent cirrhotic liver. The REmax and slope of DNs were significantly lower than adjacent cirrhotic liver parenchyma. Although the Tp of DNs was delayed two to three seconds compared to adjacent cirrhotic liver, there was no significant difference between them. CONCLUSION: Perfusion-weighted MRI detected the intranodular hemodynamic characteristics of DNs and HCCs in an experimental rat model. DNs were hypovascular compared to cirrhotic liver, while HCCs were markedly hypervascular. |
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Authors:
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Hui Xu; Jing-Xia Xie; Xuan Li; Zheng-Han Yang; Zhuo-Zhao Zheng; Bin Wang; Zheng Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 27 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-27 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 102-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, Peking University Third Hospital, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / blood supply*, pathology Contrast Media Disease Models, Animal Gadolinium DTPA Hemodynamics Liver Cirrhosis / pathology Liver Neoplasms / blood supply*, pathology Magnetic Resonance Imaging / methods* Male Precancerous Conditions / blood supply*, pathology Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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