| Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. | |
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MedLine Citation:
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PMID: 19958749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular smooth muscle cell (VSMC) proliferation remains a major cause of veno-arterial graft failure. We hypothesised that exposure of venous SMCs to arterial pressure would increase KLF5 expression and that of cell cycle genes. Porcine jugular veins were perfused at arterial or venous pressure in the absence of growth factors. The KLF5, c-myc, cyclin-D and cyclin-E expression were elevated within 24h of perfusion at arterial pressure but not at venous pressure. Arterial pressure also reduced the decline in SM-myosin heavy chain expression. These data suggest a role for KLF5 in initiating venous SMCs proliferation in response to arterial pressure. |
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Authors:
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Emre Amirak; Mustafa Zakkar; Paul C Evans; Paul R Kemp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-02 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 391 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-15 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 818-23 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Section of Molecular Medicine, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / genetics* Cell Cycle / genetics* Cell Proliferation* Cyclin D / genetics Cyclin E / genetics Gene Expression Regulation* Kruppel-Like Transcription Factors / genetics* Myocytes, Smooth Muscle / metabolism* Proto-Oncogene Proteins c-myc / genetics Swine Veins / cytology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Cyclin D; 0/Cyclin E; 0/Kruppel-Like Transcription Factors; 0/Proto-Oncogene Proteins c-myc |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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