Document Detail

Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.
MedLine Citation:
PMID:  19958749     Owner:  NLM     Status:  MEDLINE    
Vascular smooth muscle cell (VSMC) proliferation remains a major cause of veno-arterial graft failure. We hypothesised that exposure of venous SMCs to arterial pressure would increase KLF5 expression and that of cell cycle genes. Porcine jugular veins were perfused at arterial or venous pressure in the absence of growth factors. The KLF5, c-myc, cyclin-D and cyclin-E expression were elevated within 24h of perfusion at arterial pressure but not at venous pressure. Arterial pressure also reduced the decline in SM-myosin heavy chain expression. These data suggest a role for KLF5 in initiating venous SMCs proliferation in response to arterial pressure.
Emre Amirak; Mustafa Zakkar; Paul C Evans; Paul R Kemp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-02
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  391     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-03-15     Revised Date:  2014-06-18    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-23     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
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MeSH Terms
Blood Pressure / genetics*
Cell Cycle / genetics*
Cell Proliferation*
Cyclin D / genetics
Cyclin E / genetics
Gene Expression Regulation*
Kruppel-Like Transcription Factors / genetics*
Myocytes, Smooth Muscle / metabolism*
Proto-Oncogene Proteins c-myc / genetics
Veins / cytology,  metabolism*
Grant Support
FS/10/006/27960//British Heart Foundation; FS/13/20/30141//British Heart Foundation; FS/13/27/30191//British Heart Foundation; PG/09/088/28058//British Heart Foundation; PG/12/82/29907//British Heart Foundation; RG/13/1/30042//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Cyclin D; 0/Cyclin E; 0/Kruppel-Like Transcription Factors; 0/Proto-Oncogene Proteins c-myc

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