Document Detail


Perfusion temperature, thyroid hormones and inflammation during pediatric cardiac surgery.
MedLine Citation:
PMID:  19822605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: During cardiopulmonary bypass (CPB) surgery there are several alterations in concentrations of thyroid hormones. Although hypothermia and inflammation have been implicated in the disturbed thyroid axis during CPB, these issues are far from clear. METHODS AND RESULTS: We measured serum/plasma concentrations of thyroid hormones and inflammatory mediators in children with body weight <10 kg, undergoing open heart surgery, randomized to mild (n=15, 32 degrees C) or moderate (n=15, 25 degrees C) hypothermia. During CPB there was a marked decrease in triiodothyronine (T3), free thyroxin (FT4) and thyroid-stimulating hormone (TSH), followed by a slight increase after 24 h, but without normalization 48 h after CPB. There was no difference in the thyroid response between the two hypothermia groups. During CPB the maximal changes in plasma levels of interleukin (IL)-6 and the chemokines, regulated on activation normal T cell expressed and secreted (RANTES) and monocyte chemoattractant protein (MCP)-1 were inversely correlated with the maximal changes in serum levels of T3. CONCLUSION: Our findings in this randomized trial do not support a role for hypothermia as a major cause of altered thyroxin responses in children undergoing CPB. Our finding may also suggest that in addition to IL-6, other inflammatory cytokines, such as chemokines, should be further investigated for their possible influence on the thyroid axis during CPB.
Authors:
Rune Eggum; Thor Ueland; Tom E Mollnes; Vibeke Videm; Arnt E Fiane; Pål Aukrust; Harald L Lindberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-10-12
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  10     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway. rune.eggum@vestreviken.no
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cardiac Surgical Procedures / adverse effects*
Cardiopulmonary Bypass / adverse effects*
Chemokine CCL2 / blood
Chemokine CCL5 / blood
Euthyroid Sick Syndromes / blood,  etiology*
Female
Humans
Hypothermia, Induced / adverse effects*
Infant
Inflammation Mediators / blood*
Interleukin-6 / blood
Male
Prospective Studies
Systemic Inflammatory Response Syndrome / blood,  etiology*
Thyroid Hormones / blood*
Thyrotropin / blood
Thyroxine / blood
Time Factors
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL2 protein, human; 0/CCL5 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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