Document Detail

Perfusion study of hypervascular hepatocellular carcinoma with SPIO.
MedLine Citation:
PMID:  16543699     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We evaluated whether a perfusion study with Resovist is useful to assess blood flow in tumors in patients with hypervascular hepatocellular carcinoma (HCC).
SUBJECTS AND METHODS: The subjects were 28 patients; the lesions consisted of 68 hypervascular HCC, 14 post-treatment nodules, and 7 hepatocellular hypovascular nodules. After rapid intravenous injection of Resovist, 7-phase imaging was performed using the single-shot echo-planar method. Diagnostic accuracy and tumor vascularity were evaluated by 3 radiologists using the alternative free response receiver operating characteristic method. Sensitivity, Az values, and positive predictive values were calculated. To assess interobserver variability, we evaluated the kappa static to measure the degree of agreement.
RESULTS: The 3 observers indicated no significant difference in Az value related to the presence or absence of a perfusion study, and only one remarked a significant difference in sensitivity. However, kappa values were better in the presence than in the absence of a perfusion study. Blood flow assessment was poor in less than 1 cm. The 3 observers showed a positive predictive value of 90% or more.
CONCLUSION: A perfusion study may facilitate the diagnosis of hypervascular HCC, improving the diagnostic accuracy.
Kazuhiro Saito; Hiroaki Shindo; Taizo Ozuki; Aimi Ishikawa; Fumio Kotake; Yoko Shimazaki; Kimihiko Abe
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     Volume:  4     ISSN:  1347-3182     ISO Abbreviation:  Magn Reson Med Sci     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-06-28     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  101153368     Medline TA:  Magn Reson Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Department of Radiology, Tokyo Medical University Kasumigaura Hospital, Ibaraki, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Hepatocellular / blood supply*,  complications,  diagnosis*
Contrast Media / administration & dosage*
Echo-Planar Imaging / methods
Hepatitis C / complications
Iron / diagnostic use*
Liver / pathology
Liver Cirrhosis / complications
Liver Neoplasms / blood supply*,  complications,  diagnosis*
Magnetite Nanoparticles
Middle Aged
Neovascularization, Pathologic / diagnosis
Observer Variation
Oxides / diagnostic use*
ROC Curve
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed
Reg. No./Substance:
0/Contrast Media; 0/Magnetite Nanoparticles; 0/Oxides; 1317-61-9/Ferumoxytol; 7439-89-6/Iron; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides

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