| Perfusion pressures and distal oxygenation in individuals with diabetes undergoing chronic hemodialysis. | |
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MedLine Citation:
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PMID: 21972765 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The number of diabetic patients worldwide was estimated to be approximately 285 million in 2010. Approximately 5% of all diabetic patients have foot ulcers, often preceded by neuropathy and delayed healing resulting from peripheral vascular disease which leads to increased risk of infection. Additionally, there is a concern that blood flow to the feet may be reduced in patients with diabetes, which may be further compounded by changes in lower extremity perfusion pressure during hemodialysis. Current laser Doppler technology provides the opportunity to identify changes in vascularityin a non-invasive fashion. MATERIALS AND METHODS: A prospective, parallel-arm, comparison, pilot study was conducted. A total of 15 patients were enrolled, ten of whom had a documented history of diabetes. All patients required hemodialysis. Peripheral perfusion and oxygenation measurements were obtained before, midway and at the conclusion of three separate dialysis sessions within a 3-week interval for each subject. RESULTS: Preliminary results indicate a significant reduction in toe pressure during and after hemodialysis in the diabetic patient group compared to the non-diabetic group. Significant differences were not found in skin perfusion measurements or in the oxygenation measurements at any time in diabetic and nondiabetic patients undergoing hemodialysis. CONCLUSION: Preliminary results suggest hemodialysis may significantly affect pressure of the lower extremities in diabetic patients. Trends from these data indicate the need to further investigate the effect of hemodialysis on techniques used to heal wounds and ulcers in patients with diabetes. |
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Authors:
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David B Kay; Susan Ray; Nairmeen Awad Haller; Michael Hewit |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society Volume: 32 ISSN: 1071-1007 ISO Abbreviation: Foot Ankle Int Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433869 Medline TA: Foot Ankle Int Country: United States |
Other Details:
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Languages: eng Pagination: 700-3 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, Nephrology Section, Akron General Medical Center, Akron, OH 44307, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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