| Perfusion pressure in kidneys of arthritic rats and the influence of L-NAME. | |
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MedLine Citation:
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PMID: 15686120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kidneys of control and arthritic rats were perfused with a hemoglobin-free perfusion fluid with simultaneous monitoring of perfusion pressure and oxygen uptake. The basal values of renal perfusion pressure were 76.3 +/- 4.63 and 59.96 +/- 3.65 mm Hg in control and arthritic rats, respectively. Infusion of 100 microM Nomega-nitro-L-arginine methyl ester (L-NAME) an inhibitor of constitutive and inducible nitric oxide synthase, increased the renal perfusion pressure to 91.6 +/- 5.52 and 106.69 +/- 8.47 mm Hg in control and arthritic rats, respectively. Oxygen uptake of kidneys from control rats was 2.48 +/- 0.74 micromol min(-1) g(-1) and that of the arthritic rats was 2.44 +/- 0.75 micromol min(-1) g(-1). These results are consistent with an increased production of hemodynamically active nitric oxide in kidneys of arthritic rats. |
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Authors:
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Willian S Taguchi; Jurandir F Comar; Djalma J Fagundes; Adelar Bracht; Fumie Suzuki-Kemmelmeier |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research communications in molecular pathology and pharmacology Volume: 113-114 ISSN: 1078-0297 ISO Abbreviation: Res. Commun. Mol. Pathol. Pharmacol. Publication Date: 2003 |
Date Detail:
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Created Date: 2005-02-02 Completed Date: 2005-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437512 Medline TA: Res Commun Mol Pathol Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Laboratory of Liver Metabolism, Department of Biochemistry, University of Maringá, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthritis / metabolism* Blood Pressure / drug effects Enzyme Inhibitors / pharmacology* Kidney / drug effects*, metabolism Male NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide / metabolism* Nitric Oxide Synthase / antagonists & inhibitors* Oxygen Consumption Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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