Document Detail

Perfusion pressure control by adenosine triphosphate given during cardiopulmonary bypass.
MedLine Citation:
PMID:  8417658     Owner:  NLM     Status:  MEDLINE    
Administration of exogenous adenosine triphosphate (ATP) as a vasodilator during cardiopulmonary bypass was assessed in consecutive adult patients (n = 24) who demonstrated a high arterial perfusion pressure (mean, > 90 mm Hg). The action of ATP was characterized by rapid induction and stabilization of the blood pressure level. The dose of ATP ranged from 0.68 to 2.68 mg/min. Within 1 minute after the administration, there was a significant reduction in the perfusion pressure from 102 +/- 18 mm Hg (mean +/- standard deviation) to 72 +/- 19 mm Hg. The ATP was then able to maintain the desired pressure of 69 +/- 12 mm Hg at 5 minutes, 67 +/- 12 mm Hg at 10 minutes, and consistent values thereafter. After the ATP administration was discontinued, there was a prompt recovery of pressure without bradyarrhythmia. The frequency and amount of inotropes used were consistent with the control group (n = 26). Although the administration of ATP reduced the increase in serum catecholamine concentration, there were no significant changes in other vasoactive mediators (eicosanoid, angiotensin II, endothelin) between the two groups during cardiopulmonary bypass. There was neither an accumulation of metabolic products (uric acid, phosphate) nor a decrease in the level of divalent cation (Ca2+), which is observed when the cations combine with phosphates or adenosine nucleotides. This study confirmed the efficacy and safety of ATP infusion during cardiopulmonary bypass.
K Hashimoto; H Kurosawa; S Horikoshi; H Miyamoto; K Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  55     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  AIM; IM    
Department of Cardiovascular Surgery, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenosine Triphosphate / administration & dosage*
Angiotensin II / blood
Blood Pressure / drug effects*,  physiology
Cardiopulmonary Bypass*
Coronary Artery Bypass
Endothelins / blood
Epinephrine / blood
Heart Defects, Congenital / physiopathology,  surgery
Heart Diseases / physiopathology,  surgery*
Heart Valve Prosthesis
Middle Aged
Norepinephrine / blood
Prostaglandins F / blood
Thromboxane B2 / blood
Vascular Resistance / drug effects*,  physiology
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Endothelins; 0/Prostaglandins F; 0/Vasodilator Agents; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 54397-85-2/Thromboxane B2; 56-65-5/Adenosine Triphosphate; 745-62-0/prostaglandin F1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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