Document Detail

Perfusion phantom: An efficient and reproducible method to simulate myocardial first-pass perfusion measurements with cardiovascular magnetic resonance.
MedLine Citation:
PMID:  22532435     Owner:  NLM     Status:  MEDLINE    
The aim of this article is to describe a novel hardware perfusion phantom that simulates myocardial first-pass perfusion allowing comparisons between different MR techniques and validation of the results against a true gold standard. MR perfusion images were acquired at different myocardial perfusion rates and variable doses of gadolinium and cardiac output. The system proved to be sensitive to controlled variations of myocardial perfusion rate, contrast agent dose, and cardiac output. It produced distinct signal intensity curves for perfusion rates ranging from 1 to 10 mL/mL/min. Quantification of myocardial blood flow by signal deconvolution techniques provided accurate measurements of perfusion. The phantom also proved to be very reproducible between different sessions and different operators. This novel hardware perfusion phantom system allows reliable, reproducible, and efficient simulation of myocardial first-pass MR perfusion. Direct comparison between the results of image-based quantification and reference values of flow and myocardial perfusion will allow development and validation of accurate quantification methods.
Amedeo Chiribiri; Andreas Schuster; Masaki Ishida; Gilion Hautvast; Niloufar Zarinabad; Geraint Morton; James Otton; Sven Plein; Marcel Breeuwer; Philip Batchelor; Tobias Schaeffter; Eike Nagel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-24
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  69     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-08-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-707     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Equipment Design
Equipment Failure Analysis
Magnetic Resonance Angiography / instrumentation*
Magnetic Resonance Imaging, Cine / instrumentation*
Myocardial Perfusion Imaging / instrumentation*
Phantoms, Imaging*
Reproducibility of Results
Sensitivity and Specificity
Grant Support
FS/10/029/28253//British Heart Foundation; FS/10/62/28409//British Heart Foundation; RE/08/003//British Heart Foundation; WT 088641/Z/09/Z//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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