| Perfusion measurement using DCE-MRI: implications for hyperthermia. | |
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MedLine Citation:
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PMID: 18214772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is today the most popular method to assess perfusion in the body. Unfortunately, the technique is mostly used to determine semiquantitative parameters like time to peak enhancement. Perfusion quantification remains challenging using DCE-MRI. The method suffers from two major limitations. First, no standardized imaging technique is available. Secondly, no standard evaluation technique for perfusion quantification has been established which accurately describes the tracer kinetics of available contrast agents. Different imaging techniques using spoiled gradient echo sequences and the basics of the evaluation are presented. To assess perfusion changes due to hyperthermia using DCE-MRI one has to take into account the systematic variation of the arterial input function required for perfusion quantification. Hyperthermia modifies the contrast agent bolus in that a shorter and more highly concentrated bolus appears earlier in the tissue. |
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Authors:
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Lutz Lüdemann; Peter Wust; Johanna Gellermann |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 24 ISSN: 0265-6736 ISO Abbreviation: Int J Hyperthermia Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-24 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
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Languages: eng Pagination: 91-6 Citation Subset: IM |
Affiliation:
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Department of Radiotherapy, Charité, CVK, Berlin, Germany. lutz.luedemann@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media Extravasation of Diagnostic and Therapeutic Materials* Humans Hyperthermia, Induced* Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods* Neoplasms / blood supply, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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