Document Detail

Perfusion linearity and its applications in perfusion algorithm analysis.
MedLine Citation:
PMID:  21871781     Owner:  NLM     Status:  Publisher    
Perfusion analysis computes blood flow parameters (blood volume, blood flow, and mean transit time) from the observed flow of a contrast agent passing through the patient's vascular system. Perfusion deconvolution has been widely accepted as the principal numerical tool for perfusion analysis, and is used routinely in clinical applications. The extensive use of perfusion in clinical decision-making makes numerical stability and robustness of perfusion computations vital for accurate diagnostics and patient safety. The main goal of this paper is to propose a novel approach for validating numerical properties of perfusion algorithms. The approach is based on the Perfusion Linearity Property (PLP), which is fundamental to virtually all perfusion data processing. PLP allows one to study perfusion values as weighted averages of the original imaging data. This, in turn, uncovers hidden problems with the existing perfusion techniques, and may be used to suggest more reliable computational approaches and methodology.
Oleg S Pianykh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society     Volume:  -     ISSN:  1879-0771     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806104     Medline TA:  Comput Med Imaging Graph     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
BIDMC, Harvard Medical School, Radiology, 330 Brookline Ave, Boston, MA 02215, United States.
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