| Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness. | |
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MedLine Citation:
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PMID: 21147163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A highly plausible etiology for Gulf War Illness (GWI) is that the neural damage and cognitive deficits are associated with excessive exposure to cholinesterase-inhibiting cholinergic stimulants. Our previous SPECT study provided strong indication that cerebral blood flow (CBF) in veterans with GWI may be different from those of unaffected control veterans. The present study confirmed and extended previous findings that patients with GWI have abnormal response to an inhibitory cholinergic challenge, physostigmine infusion, when compared to age-gender-education matched control veterans. The MRI-based arterial spin labeling (ASL) and phase-contrast techniques have several key advantages over SPECT, including shorter experiment duration, complete non-invasiveness, and higher spatial and temporal resolutions, and therefore may provide a cost-effective biomarker for characterization of GWI. |
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Authors:
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Peiying Liu; Sina Aslan; Xiufeng Li; David M Buhner; Jeffrey S Spence; Richard W Briggs; Robert W Haley; Hanzhang Lu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-12-13 |
Journal Detail:
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Title: Neurotoxicology Volume: 32 ISSN: 1872-9711 ISO Abbreviation: Neurotoxicology Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2012-01-25 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 242-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cerebrovascular Circulation / drug effects*, physiology Cholinergic Agents / administration & dosage Cholinesterase Inhibitors / administration & dosage* Gulf War Humans Magnetic Resonance Imaging* / methods Male Middle Aged Persian Gulf Syndrome / diagnosis*, metabolism, psychology Physostigmine / administration & dosage* Regional Blood Flow / drug effects, physiology Veterans* / psychology |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024982-05/RR/NCRR NIH HHS; UL1RR024982/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Agents; 0/Cholinesterase Inhibitors; 57-47-6/Physostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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