| Perfusion-contractility matching during Fontan circulation. | |
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MedLine Citation:
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PMID: 12465342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the relationship between coronary perfusion pressure (CPP) and myocardial contractility and the effects of an acute elevation of right atrial pressure (RAP) on this relationship in an experimental model of Fontan circulation in 6 anesthetized open-chest dogs with isolated perfused coronary arteries. The relationship between CPP and Ees could be described by biphasic J-shaped curves which were nearly identical before and under Fontan circulation. While above a "critical" CPP (72 +/- 9 mmHg vs. 81 +/- 8 mmHg, n.s.) the changes of CPP did not affect Ees, below this level the decrease of CPP resulted in a progressive decrease of Ees. Under Fontan circulation, the progressive increase of RAP did not influence Ees at CPP = 100 mmHg, led to a moderate decrease of Ees at CPP = 75 mmHg and severe decrease at CPP = 60 mmHg. Thus, both coronary arterial and venous pressure affect myocardial contractility after Fontan procedure. |
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Authors:
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G Szabó; V Buhmann; A Graf; S Melnitchuk; S Hagl; C F Vahl |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedizinische Technik. Biomedical engineering Volume: 47 Suppl 1 Pt 2 ISSN: 0013-5585 ISO Abbreviation: Biomed Tech (Berl) Publication Date: 2002 |
Date Detail:
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Created Date: 2002-12-05 Completed Date: 2003-03-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1262533 Medline TA: Biomed Tech (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 912-4 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, University of Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology* Coronary Circulation / physiology* Dogs Fontan Procedure* Myocardial Contraction / physiology* Postoperative Complications / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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