| Perfusion computed tomographic assessment of early hepatocellular carcinoma in cirrhotic liver disease: initial observations. | |
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MedLine Citation:
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PMID: 19204443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To prospectively assess perfusion computed tomography (CT) for evaluation of tumor vascularity of early hepatocellular carcinoma (HCC) in patients with cirrhosis. METHODS: The study cohort included 30 patients who had Child-Pugh class A or B liver cirrhosis and a single histopathologically confirmed HCC not exceeding 3 cm in diameter. All patients underwent perfusion CT study using a multidetector 16-slice CT. Four perfusion parameters were measured for the HCCs and cirrhotic liver parenchyma: hepatic perfusion (HP), blood volume (BV), arterial perfusion (AP), and time to peak (TTP). Perfusion parameters were described with quartile (qt) values of their distribution; univariate paired Wilcoxon signed rank test was used for statistical analysis. RESULTS: The values of perfusion parameters measured within tumor tissue were the following: HP (milliliters per 100 g per minute): median = 45.7 (first qt = 35.3; third qt = 61.3); BV (milliliters per 100 mg): median = 20.6 (first qt = 13.0; third qt = 27.6); AP (milliliters per minute): median = 44.2 (first qt = 36.7; third qt = 57.0); TTP (seconds): median = 18.7 (first q = 15.9; third qt = 24.0). Our data showed that HP, BV, and AP values were higher (P < 0.001), whereas TTP was lower (P < 0.001), in HCCs relative to the cirrhotic liver parenchyma. For all the CT perfusion parameters calculated, there was a significant difference between HCC and background cirrhotic liver. CONCLUSIONS: Preliminary results suggest that in patients with cirrhosis and early HCC, perfusion CT is a feasible technique for noninvasive assessment of tumor vascularity. |
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Authors:
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Davide Ippolito; Sandro Sironi; Massimo Pozzi; Laura Antolini; Laura Ratti; Franca Meloni; Francesca Invernizzi; Maria Grazia Valsecchi; Ferruccio Fazio |
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9448763 - Double phase ct arteriography of the whole liver in the evaluation of hepatic tumors. 8273693 - Passive hepatic congestion: cross-sectional imaging features. 9448763 - Double phase ct arteriography of the whole liver in the evaluation of hepatic tumors. |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 32 ISSN: 1532-3145 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2009-02-10 Completed Date: 2009-03-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 855-8 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, School of Medicine, University of Milano-Bicocca, Milan, Italy. davide.atena@tiscalinet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Hepatocellular / radiography* Female Humans Liver Cirrhosis / radiography* Liver Neoplasms / radiography* Male Middle Aged Perfusion Pilot Projects Precancerous Conditions / radiography* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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