Document Detail


Perfusion abnormalities in congenital and neoplastic pulmonary disease: comparison of MR perfusion and multislice CT imaging.
MedLine Citation:
PMID:  15875195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to assess magnetic resonance (MR) perfusion patterns of chronic, non-embolic pulmonary diseases of congenital and neoplastic origin and to compare the findings with results obtained with pulmonary, contrast-enhanced multislice computed tomography (CT) imaging to prove that congenital and neoplastic pulmonary conditions require MR imaging over the pulmonary perfusion cycle to successfully and directly detect changes in lung perfusion patterns. Twenty-five patients underwent concurrent CT and MR evaluation of chronic pulmonary diseases of congenital (n=15) or neoplastic (n=10) origin. Analysis of MR perfusion and contrast-enhanced CT datasets was realized by defining pulmonary and vascular regions of interest in corresponding positions. MR perfusion calculated time-to-peak enhancement, maximal enhancement and the area under the perfusion curve. CT datasets provided pulmonary signal-to-noise ratio measurements. Vessel center-lines of bronchial arteries were determined. Underlying perfusion type, such as pulmonary arterial or systemic arterial supply, as well as regions with significant variations in perfusion were determined statistically. Analysis of the pulmonary perfusion pattern detected pulmonary arterial supply in 19 patients; six patients showed systemic arterial supply. In pulmonary arterial perfusion, MR and multislice CT imaging consistently detected the perfusion type and regions with altered perfusion patterns. In bronchial arterial supply, MR perfusion and CT imaging showed significant perfusion differences. Patients with bronchial arterial supply had bronchial arteries ranging from 2.0 to 3.6 mm compared with submillimeter diameters in pulmonary arterial perfusion. Dynamic MR imaging of congenital and neoplastic pulmonary conditions allowed characterization of the pulmonary perfusion type. CT imaging suggested the presence of systemic arterial perfusion by visualizing hypertrophied bronchial arteries.
Authors:
Daniel T Boll; Jonathan S Lewin; Philip Young; Ernest S Siwik; Robert C Gilkeson
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-05-05
Journal Detail:
Title:  European radiology     Volume:  15     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-10     Completed Date:  2005-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1978-86     Citation Subset:  IM    
Affiliation:
Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106-5056, USA. boll@uhrad.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Bronchial Arteries / pathology,  radiography
Child
Child, Preschool
Contrast Media
Female
Humans
Image Enhancement
Image Processing, Computer-Assisted / methods*
Lung Diseases / congenital*,  pathology
Lung Neoplasms / blood supply,  congenital*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Pulmonary Artery / abnormalities,  pathology,  radiography
Pulmonary Circulation / physiology*
Radiographic Image Enhancement
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
0/Contrast Media

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