Document Detail


Perfusion pressure and movement-induced hyperemia: evidence of limited vascular function and vasodilatory reserve with age.
MedLine Citation:
PMID:  23262136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To better understand the mechanisms contributing to reduced blood flow with age, this study sought to elucidate the impact of altered femoral perfusion pressure (FPP) on movement-induced hyperemia. Passive leg movement was performed in 10 young (22 ± 1 yr) and 12 old (72 ± 2 yr) healthy men for 2 min, with and without a posture-induced change in FPP (~7 ± 1 ΔmmHg). Second-by-second measurements of central and peripheral hemodynamic responses were acquired noninvasively (finger photoplethysmography and Doppler ultrasound, respectively), with FPP confirmed in a subset of four young and four old subjects with arterial and venous catheters. Central hemodynamic responses (heart rate, stroke volume, cardiac output, mean arterial pressure) were not affected by age or position. The young exhibited a ~70% greater movement-induced peak change in leg blood flow (ΔLBF(peak)) in the upright-seated posture (supine: 596±68 ml/min; upright: 1,026 ± 85 ml/min). However, in the old the posture change did not alter ΔLBF(peak) (supine: 417±42 ml/min; upright: 412±56 ml/min), despite the similar increases in FPP. Similarly, movement-induced peak change in leg vascular conductance was ~80% greater for the young in the upright-seated posture (supine: 7.1 ± 0.8 ml·min(-1)·mmHg(-1); upright: 12.8 ± 1.3 ml·min(-1)·mmHg(-1)), while the old again exhibited no difference between postures (supine: 4.7 ± 0.4 ml·min(-1)·mmHg(-1); upright: 4.8 ± 0.5 ml·min(-1)·mmHg(-1)). Thus this study reveals that, unlike the young, increased FPP does not elicit an increase in movement-induced hyperemia or vasodilation in the old. In light of recent evidence that the majority of the first minute of passive movement-induced hyperemia is predominantly nitric oxide (NO) dependent in the young, these findings in the elderly may be largely due to decreased NO bioavailability, but this remains to be definitively determined.
Authors:
H Jonathan Groot; Joel D Trinity; Gwenael Layec; Matthew J Rossman; Stephen J Ives; Russell S Richardson
Related Documents :
11771866 - Renovascular hypertension in children.
23288166 - Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular cont...
10597086 - Seasonal variation in the occurrence of nontraumatic rupture of thoracic aorta.
23533716 - Characterisation of hypertensive patients with improved endothelial function after dark...
10708466 - Reconstruction of 3-dimensional right ventricular shape and volume from 3 orthogonal pl...
15737246 - Carbon dioxide elimination and gas displacement vary with piston position during high-f...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-12-21
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  304     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-04-15     Revised Date:  2014-02-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H610-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology*
Blood Flow Velocity / physiology
Cardiac Output / physiology
Catheterization, Peripheral / methods
Femoral Artery / physiology,  ultrasonography
Femoral Vein / physiology,  ultrasonography
Fingers / physiology
Heart Rate / physiology
Humans
Hyperemia / physiopathology*,  ultrasonography
Leg / blood supply*,  physiology,  ultrasonography
Male
Movement / physiology*
Photoplethysmography / methods
Posture / physiology
Ultrasonography, Doppler / methods
Vascular Resistance / physiology
Vasodilation / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
P01-H1-091830//PHS HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent ...
Next Document:  The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signal...