| Perfusion MRI in neuro-psychiatric systemic lupus erthemathosus. | |
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MedLine Citation:
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PMID: 20677252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To use perfusion weighted MR to quantify any perfusion abnormalities and to determine their contribution to neuropsychiatric (NP) involvement in systemic lupus erythematosus (SLE). MATERIALS AND METHODS: We applied dynamic susceptibility contrast (DSC) perfusion MRI in 15 active NPSLE, 26 inactive NPSLE patients, and 11 control subjects. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) maps were reconstructed and regions of interest were compared between groups. In addition, the effect of SLE criteria, NPSLE syndromes, immunological coagulation disorder, and medication on CBF, CBV, and MTT was investigated. RESULTS: No significant differences were found between the groups in CBF, CBV, and MTT. No significant influence of SLE criteria or NPSLE syndromes on CBF, CBV, or MTT was found. No significant influence of anti-cardiolipin antibodies, lupus anti-coagulant, the presence of anti-phospholipid syndrome (APS), or medication on CBF, CBV, or MTT was found. CONCLUSION: Our findings suggest CBF, CBV, and MTT in the white and the gray matter in SLE patients is not significantly different from healthy controls or between patients with and without specific symptoms or with and without immunological disorder involving coagulation. |
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Authors:
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Bart J Emmer; Matthias J van Osch; Ona Wu; Gerda M Steup-Beekman; Stefan C Steens; Tom W Huizinga; Mark A van Buchem; Jeroen van der Grond |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Copyright Information:
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2010 Wiley-Liss, Inc. |
Affiliation:
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Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands. b.j.emmer@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation Disorders / pathology Cardiolipins / immunology Case-Control Studies Cerebrovascular Circulation Contrast Media / pharmacology Female Humans Lupus Erythematosus, Systemic / complications, diagnosis*, pathology Magnetic Resonance Imaging / methods Male Mental Disorders / complications, diagnosis*, pathology Middle Aged Perfusion Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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